Method for detecting inhibitors of tat protein

Details Method for detecting inhibitors of tat protein Method for detecting inhibitors of tat protein

1989-02-06

1994-01-11

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 71, 530350, G01N 33569

Patent

active

052780422

ABSTRACT:
A method for evaluating the inhibitory effect of a substance on tat-protein TAR RNA binding is described. A test system for determining the association of tat-protein with TAR RNA is also included within the scope of the invention.

REFERENCES:
Muesing et al: Regulation of mRNA Accumulation by HIV trans-Activator Protein, Cell v48, pp. 691-701, Feb. 27, 1987.
Wu, F. et al (I) Alterations in Binding Char . . . Enhancer Factor J. of Virology Jan. '88 pp. 218-225.
Wu, F. et al, (II) Purification of . . . EBP-1 and UBP-1 EMBO Journal vol. 7 #7 pp. 2117-2129 Jul. '88.

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