Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-10-03
2006-10-03
Swope, Sheridan L. (Department: 1656)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S388260, C530S389100
Reexamination Certificate
active
07115382
ABSTRACT:
Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A) are described. Methods for identifying agents that alter the protease activity of PAPP-A, and pharmaceutical compositions and medical devices that include such agents are also described.
REFERENCES:
patent: 5876433 (1999-03-01), Lunn
patent: 6172198 (2001-01-01), Sinosich
patent: WO 94/21686 (1994-09-01), None
patent: WO 99/32620 (1999-07-01), None
patent: WO 00/54806 (2000-09-01), None
de Boer et al, Atherosclerosis, Inflammation, and infection. J Pathol. Feb. 2000;190(3):237-43. Review.
Jacot et al, Effect of glucose on insulin-like growth factor binding protein-4 proteolysis. Endocrinology. Jan. 1998;139(1):44-50.
Kirpichnikov et al Diabetes mellitus and diabetes-associated vascular disease. Trends Endocrinol Metab. Jul. 2001;12(5):225-30. Review.
Oxvig et al Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J Biol Chem. Jun. 15, 1993:268(17):12243-6.
Epstein et al Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc Natl Acad Sci U S A. Nov. 1, 1992:89(21);10435-9.
Harlow and Lane Immunoaffinity pruification of antibodies on an antigen column In: Antibodies, a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. pp 313.
Mazerbourg et al. The insulin-like growth factor system: a key determinant role in the growth and selection of ovarian follicles? a comparative species study. Reprod Domest Anim. Aug. 2003;38(4):247-58 Review.
Govoni et al. The multi-functional role of insulin-like growth factor binding proteins in bone. Pediatr Nephrol. Mar. 2005;20(3):261-8.
Mohan et al. Insulin-like growth factor system components and the coupling of bone formation to resorption. Horm Res. 1996;45 Suppl 1;59-62.
Lawrence et al., “Characterization and partial purification of the insulin-like growth factor (GF)-dependent IGF binding protein-4-specific protease from human fibroblast conditioned media,” Growth Hormone & IGF Research, 1999, 9:25-34.
GenBank Accession No. J02642.
GenBank Accession No. J04038.
GenBank Accession No. M10277.
GenBank Accession No. M34462.
GenBank Accession No. X00351.
GenBank Accession No. X14088.
GenBank Accession No. X68280.
Ausubel et al. (eds.),Short Protocols In Molecular Biology, 2ndEdition, 1992, Chapter 11, Greene Publishing Associates and John Wiley & Sons, New York, pp. 11-1—11-54.
Bersinger and Klopper, “The pattern of serum levels of pregnancy-associated plasma protein A (PAPP-A) during the ovulatory mentrual cycle,”Br. J. Obstet. Gynaecol., 1984, 91;1245-1248.
Bischof et al., “Is pregnancy-associated plasma protein A a tumor marker?”Am. J. Obstet. Gynecol., 1982, 143:379.
Bono et al., “Localization of Pregnancy-Associated Plasma Protein-A and Colocalization of Prenancy-Associated Plasma Protein-A Messenger Ribonucleic Acid and Eosinophil Granule Major Basic Protein Messenger Ribonucleic Acid in Placenta,”Lab. Invest., 1994, 71(4);560-566.
Cataldo et al., “Regulation of Insulin-Like Growth Factor Binding Protein Production by Human Luteinizing Granulosa Cells Cultured in Defined Medium,”J. Clin. Endocrinol. Metab., 1993, 76:207-215.
Cataldo et al., “Interferon-γ and Activin A Promote Insulin-Like Growth Factor-Binding Protein-2 and -4 Accumulation by Human Luteinizing Granulosa Cells, and Interferon-γ Promotes Their Apoptosis,”J. Clin. Endocrinol. Metab., 1998, 83:179-186.
Chandrasekher et al., “Estrogen- But Not Androgen-Dominant Human Ovarian Follicular Fluid Contains an Insulin-Like Growth Factor Binging Protein-4 Protease,”J. Clin. Endocrinol. Metab., 1995, 80(9):2734-2739.
Chandrasekher et al., “Role of Insulin-Like Growth Factor Binding Protein-4 (IGFBP-4) and IGFBP-4 Protease in Human Granulosa Cell Function,”Proceedings of the 28thAnnual Meeting of the Society for the Study of Reproduction, 1995, Davis, California, pp. 82, Abstratct # 102.
Conover et al., “Posttranslational Regulation of Insulin-like Growth Factor Binding Protein-4 in Normal and Transformed Human Fibroblasts,”J. Clin. Invest., 1993, 91:1129-1137.
Conover et al., “Evidence That The Insulin-Like Growth Factor Binding Protein-4 Protease In Human Ovarian Follicular Fluid Is Pregnancy Associated Plasma Protein-A,”J. Clin. Endocrinol. Metab., 1999, 84(12):4742-4745.
Durham et al., “Alterations in Insulin-Like Growth Factor (IGF)-Dependent IGF-Binding Protein-4 Proteolysis in Transformed Osteoblastic Cells,”Endocrinology, 1995, 136(4):1374-1380.
Haaning et al., “Complete cDNA sequence of the preproform of human pregnancy-associated plasma protein-A—Evidence for expression in the brain and induction by cAMP,”Eur. J. Biochem., 1996, 237:159-163.
Huse et al., “Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda,”Science, 1989, 246:1275-1281.
Iwashita et al., “Physiological Role of Insulin-Like-Growth-Factor-Binding Protein-4 in Human Folliculogenesis,”Horm. Res., 1996, 46(Suppl. 1):31-36.
Kristensen et al., “Amino Acid Sequence of Human Pregnancy-Associated Plasma Protein-A Derived from Cloned cDNA,”Biochem., 1994, 33:1592-1598.
Kuhajda and Eggleston, “Pregnancy-Associated Plasma Protein A,”Am. J. Pathol., 1985, 121:342-348.
Lawrence et al., “The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A,”Proc. Natl. Acad. Sci. USA, 1999, 96:3149-3153.
Lin et al., “Characterization of four human pregnancy-associated plasma proteins,”Am. J. Obstet. Gynecol., 1974, 118(2):223-236.
Overgaard et al., “Messenger Ribonucleic Acid Levels of Pregnancy-Associated Plasma Protein-A and the Proform of Eosinophil Major Basic Protein: Expression in Human Reproductive and Nonreproductive Tissues,”Biology of Reproduction, 1999, 61:1083-1089.
Oxvig et al., “Isolation and characterization of circulating complex between human pregnancy-associated plasma protein-A and proform of eosinophil major basic protein,”Biochim. Biophys. Acta, 1994, 1201:415-423.
Qin et al., “Double-monoclonal immunofluorometric assays for pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/proMBP) complex in first-trimester maternal serum screening for Down syndrome,”Clin. Chem., 1997, 43(12):2323-2332.
Qin et al., “Studies on the Role of Human Insulin-like Growth Factor-II (IF-II)-Dependent IGF Binding Protein (hIGFBP)-4 Protease in Human Osteoblasts Using Protease-Resistant IGFBP-4 Analogs,”J. Bone Mineral Res., 1999, 14(12):2079-2088.
Schwartz et al., “Restenosis After Balloon Angioplasty—A Practical Proliferative Model in Porcine Coronary Arteries,”Circulation, 1990, 82:2190-2200.
Seppäläet al., “Pregnancy Proteins in Seminal Plasma, Seminal Vesicles, Preovulatory Follicular Fluid, and Ovary,”Annals of the New York Academy of Sciences, 1985, 442:212-226.
Sjöberg et al., “Hypertimulated human preovulatory follicular fluid, luteinized cells of unruptured follicles, and corpus luteum contain pregnancy-associated plasma protein A (PAPP-A),”Fertility and Sterility, 1984, 41(4):551-557.
Van Dessel et al., “Serum and Follicular Fluid Levels of Insulin-Like Growth Factor I (IGF-I), IGF-II, and IGF-Binding Protein-1 and —3 during the Normal Menstrual Cycle,”J. Clin. Endocrinol. Metab., 1996, 81(3):1224-1231.
Conover Cheryl A.
Overgaard Michael Toft
Oxvig Claus
Como Holdings APS
Fish & Richardson P.C. P.A.
Mayo Foundation for Medical Education and Research
Swope Sheridan L.
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