Method for detecting HTLV-III neutralizing antibodies in sera

Details Method for detecting HTLV-III neutralizing antibodies in sera Method for detecting HTLV-III neutralizing antibodies in sera

1987-04-20

1988-07-05

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 435 29, 435 32, 4352402, 435948, 436506, 436510, G01N 33569, G01N 33564, C12Q 170

Patent

active

047554576

ABSTRACT:
This invention relates to a method to measure natural human antibodies in sera which will neutralize HTLV-III infection in an in vitro assay. Basically, cell-free virus is incubated with serum and used to infect H9 cells, which are then put in culture for three days, and viral infectivity is assayed using a monoclonal antibody specific for HTLV-III p24 in an immune fluorescent assay.

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