Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1995-08-04
1998-03-10
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 692, 435 696, 436 69, 530380, 530381, 530382, 530383, 530384, 530385, 514834, C12Q 156
Patent
active
057260281
ABSTRACT:
The present invention relates to a method for detecting disturbances of the protein C/protein S system.
REFERENCES:
patent: 5308756 (1994-05-01), Van De Waart et al.
Duchemin et al. (1994) Thromb. Hemostas. 71(3):331-8.
Becker et al. (1985) Thromb. Res. 40: 721-30.
Esmon, C.T., "Protein S and Protein C Biochemistry, Physiology, and Clinical Manifestation of Deficiencies," TCM 2 (6) :214-19 (1992).
Rick et al., "Factor IXa and von Willebrand Factor Modify the Inactivation of Factor VIII by Activated Protein C," J. Lab. Clin. Med. 115(4):415-21 (1990).
Amer et al., "Impairment of the Protein C Anticoagulant Pathway in a Patient with Systemic Lupus Erythematosus, Anticardiolipin Antibodies and Thrombosis," Thromb. Res. 57(2):247-58 (1990).
Bertina et al., "Mutation in Blood Coagulation Factor V Associated with Resistance to Activated Protein C," Nature 369:64-67 (1994).
Bertina, R.M., "Specificity of Protein C and Protein S Assays," Res. Clin. Lab. 20:127-38 (1990).
Duchemin et al., "A New Assay Based on Thrombin Generation Inhibition to Detect Both Protein C and Protein S Deficiencies in Plasma," Thromb. Haemost. 71(3):331-38 (1994).
European Search Report, dated Nov. 9, 1995.
Behring Diagnostics GmbH
Saidha Tekchand
Wax Robert A.
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