Method for detecting disturbances of the protein c/protein s sys

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor

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435 692, 435 696, 436 69, 530380, 530381, 530382, 530383, 530384, 530385, 514834, C12Q 156

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active

057260281

ABSTRACT:
The present invention relates to a method for detecting disturbances of the protein C/protein S system.

REFERENCES:
patent: 5308756 (1994-05-01), Van De Waart et al.
Duchemin et al. (1994) Thromb. Hemostas. 71(3):331-8.
Becker et al. (1985) Thromb. Res. 40: 721-30.
Esmon, C.T., "Protein S and Protein C Biochemistry, Physiology, and Clinical Manifestation of Deficiencies," TCM 2 (6) :214-19 (1992).
Rick et al., "Factor IXa and von Willebrand Factor Modify the Inactivation of Factor VIII by Activated Protein C," J. Lab. Clin. Med. 115(4):415-21 (1990).
Amer et al., "Impairment of the Protein C Anticoagulant Pathway in a Patient with Systemic Lupus Erythematosus, Anticardiolipin Antibodies and Thrombosis," Thromb. Res. 57(2):247-58 (1990).
Bertina et al., "Mutation in Blood Coagulation Factor V Associated with Resistance to Activated Protein C," Nature 369:64-67 (1994).
Bertina, R.M., "Specificity of Protein C and Protein S Assays," Res. Clin. Lab. 20:127-38 (1990).
Duchemin et al., "A New Assay Based on Thrombin Generation Inhibition to Detect Both Protein C and Protein S Deficiencies in Plasma," Thromb. Haemost. 71(3):331-38 (1994).
European Search Report, dated Nov. 9, 1995.

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