Chemistry: analytical and immunological testing – Biological cellular material tested
Reexamination Certificate
2007-01-09
2007-01-09
Wallenhorst, Maureen M. (Department: 1743)
Chemistry: analytical and immunological testing
Biological cellular material tested
C435S002000, C435S004000, C435S029000
Reexamination Certificate
active
10505828
ABSTRACT:
The invention concerns a method for the diagnosis of membrane channel defects in cells by comparing defective with non-defective cells with the following steps: influencing the volume regulation of the cells; recording the change of volume regulation resulting therefrom in non-defective cells; determining the existence of defective cells with a volume change deviating therefrom, in order to provide a suitable method which enables the identification of diseases based on CFTR defects, in particular cystic fibrosis, at an early stage.
REFERENCES:
Braunstein et al. The Journal of Biological Chemistry, vo. 276, No. 9, Mar. 2, 2001,pp. 6621-6630.
Bronsveld et al. The Journal of Clinical Investigation, vol. 108, No. 11, Dec. 2001, pp. 1705-1715.
Reddy et al. Journal of Membrane Biology, vol. 189, 2002, pp. 15-25.
Schultz et al. Physiological Reviews, vol. 79, suppl., No. 1, Jan. 1999, pp. S109-S144.
Suleymanian et al. Journal of Molecular and Cellular Cardiology, vol. 27, 1995, pp. 721-728.
Oberleithner Hans
Schillers Hermann
Thorpe North & Western LLP
Wallenhorst Maureen M.
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