Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-06-27
2008-08-12
Whisenant, Ethan (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300
Reexamination Certificate
active
07410762
ABSTRACT:
A method for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least one surface of the conducting electrode. The film is functionalized with probe molecules that chemically interact with the target biomolecules at the film surface, blocking indicator molecules present in solution from diffusing from the solution to the electrode, thereby changing the electrochemical response of the electrode.
REFERENCES:
patent: 6051380 (2000-04-01), Sosnowski et al.
patent: 6238624 (2001-05-01), Heller et al.
patent: 6342359 (2002-01-01), Lee et al.
patent: 6387625 (2002-05-01), Eckhardt et al.
patent: 6484046 (2002-11-01), Say et al.
patent: 6548311 (2003-04-01), Knoll
patent: 6740518 (2004-05-01), Duong et al.
patent: 6846638 (2005-01-01), Shipwash
Hyun C. Yoon, Biocatalitic precipitation induced by an affinity reaction on dendrimer-activated surfaces for the electrochemical signaling from immunosensors., The Analyst, 2002, 127, p. 1082-1087.
E. Palecek, DNA hydridization at microbeads with cathodic stripping voltammetric detection, Talanta 56 (2002) p. 919-930.
Joseph Wang, Indicator-free electrochemical DNA hybridization biosensor, Analytica Chimica Acta 375 (1998) p. 197-203.
Chunhai Fan, Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA, PNAS, vol. 100, No. 16, (Aug. 5, 2003) 9134-9137.
Christine Berggren, Capacitance Measurements of Antibody-Antigen Interactions in a Flow System, Anal. Chem. 1997, 69, 3651-3657.
Lievin Kumpumbu-Kalemba, Electrochemical characterization of monolayers of a biotinylated polythiophene: towards the development of polymeric biosensors, Chem. Commun., 2000, 1847-1848.
Huo Qisheng
Liu Jun
Klavetter Elmer A.
Sandia Corporation
Whisenant Ethan
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