Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence
Patent
1997-11-17
1999-12-07
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Diagnostic or test agent produces in vivo fluorescence
424 111, 424 117, 424 91, A61K 4900, G01N 3100, G01N 3348
Patent
active
059978465
ABSTRACT:
The present invention provides a method for detecting chitin-containing organisms on an area of a person or animal by contacting the particular area with a dye that is capable of biding to chitin and emitting fluorescence upon exposure to light. If a chitin-containing organism is present in the treated area, the chitin of the organism will bind the dye and, upon exposure to light, the chitin-containing organisms may be visualized and removed. Also provided by the present invention are solutions and suspensions that contain a dye capable of binding to a chitin-containing organism and emitting florescence upon exposure to light. The solutions and suspensions provided herein may be in the form of a shampoo, cream, lotion or detergent for the detection of chitin-containing organisms present in body hair, on the skin, clothing or the fur of animals. The solutions and suspensions may also be in a form suitable for spraying on clothes, as well as on the hair, skin and fur. Further provided by the present invention are kits comprising a solution or suspension that contains a dye capable of binding to a chitin-containing organism and a source of light that emits a wavelength capable of emitting fluorescence of the dye upon exposure to the light.
REFERENCES:
patent: 4380790 (1983-04-01), Saferstein
patent: 5004699 (1991-04-01), Winters
patent: 5292504 (1994-03-01), Cardin et al.
patent: 5353803 (1994-10-01), Cerra
patent: 5547665 (1996-08-01), Upton
patent: 5561051 (1996-10-01), Silverman
patent: 5587292 (1996-12-01), Laine et al.
J. Vavra, et al., Staining of Microsporidian Spores by Optical Brighteners with remarks on the use of Brighteners for the Diagnosis of Aids Associated Human Microsporidioses, Folia Parasitologica, pp. 267-272 (1993).
Sutphin, et al.,Improved detection of Oculomycoses using induced fluorescence with celluflor, Opthalmology, 416-417, (1996).
Conteas, et al., Fluorescence Techniques for Diagnosing Intestinal Microsporidiosis in Stool, Enteric Fluid and Biopsy Specimens from Acquired Immunodeficiency Syndrome patients with chronic diarrhea, Arch Pathol. Lab. Med., vol. 120, Sep. 1996.
Hegeage, Jr., et al., Use of Calcoflour White in Clinical Mycology, Laboratory Medicine, vol. 15, No. 2, Feb. 1984, pp. 109-112.
Hoffgen, et al., The use of Funguigual A as a fluorescent dye in Medical Mycology, Aktuel-Dermatol., vol. 15 No. 7, 1989, pp. 216-20 (English Abstract only).
Hejtmanek, et al., Fluorescence Microscopy detection of Mycopathogens using Rylux BSU, Cesk Patol, 1989, Nov. 25(4) : 244-50 (English Abstract only).
Raclavsky, et al., Quantitative determination of yeast in sputum--a direct microscopy method, Cesk Epidemiol Mikrobiol Immunol, 1989 May; 38(3) : 161-6 (English Abstract only).
Costello, "This Gizmo Could Just Bring Out a Little Compulsiveness in Us All," Wall Street Journal, Oct. 13, 1998, Section B, P. 1.
Oswald, et al., Quantitative fluorometric analysis of plant and microbial chitosanases, Anal . Biochem. 1992 Jul.; 204(1) : 40-6.
Carrano, et al., Dansyl N-acetyl glucosamine as a precursor of fluorescent chitin: a method to detect fungal cell wall inhibitors, J. Antibiot (Tokyo)1997 Feb.; 50(2): 177-9.
Trudel, et al., Detection of chitin deacetylase activity after polyaciylamide gel electrphoresis, Anal. Biochem. 1990 Sep.; 189(2) : 249-253.
Borg-Von Zepelin, Fluorescence assay for the detection of adherent candida yeasts to target cells in microtest plates, Mycoses1995 Sep.-Oct.: 38(9-10): 339-347.
Dox et al (1993), The Harper Collins Illustrated Medical Dictionary, pp. 96,177,253,276, 336, 480, 531.
Burns Edward R.
Faskowitz Fagie
Wittner Murray
Albert Einstein College of Medicine of Yeshiva University
Hollinden Gary E.
Joneson Dameron
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