Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-03-20
2011-10-04
Skelding, Zachary (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007240
Reexamination Certificate
active
08030005
ABSTRACT:
The present invention comprises a method for the quantitative or qualitative detection of antigen-specific CD4+ T cells and/or CD8+ T cells in a subject, said method comprising quantitatively or qualitatively detecting the expression of cell surface marker CD25 and one or more of cell surface markers CD134 and CD137 in a suitable lymphocyte-containing sample from said subject in response to exposure to an antigen. A method for determining the immunocompetence of a subject and a method for isolating antigen-specific CD4+ and/or CD8+ T cells is also disclosed.
REFERENCES:
patent: 2005/0196386 (2005-09-01), Blazar et al.
patent: WO00 11476 (2000-03-01), None
Kotani et al. Blood. Nov. 15, 2001;98(10):3162-4.
Wang et al. The Journal of Immunology, 2002, 169: 4717-4722.
Supplementary European Search Report dated Mar. 4, 2009, for European Patent Application No. 07718589.0; Applicant, St. Vincent's Hospital Sydney Limited.
Sanchez, Joaquin et al., Kinetic of Regulatory CD25highand Activated CD134+(OX40) Tlymphocytes During Acute and Chronic Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation. British Journal of Haematology, 126, 697-703.
Miura, Y. et al. Regulation of OX40 Gene Expression in Graft-Versus-Host Disease. Transplantation Proceedings, 37, 57-61 (2005).
van Amelsfort, J. M. R. et al. “CD4 + CD25 Regulatory T Cells in Rheumatoid Arthritis.” Arthritis & Rheumatism, vol. 50, No. 9, Sep. 2004, pp. 2775-2785.
Gummert, J. F. et al. “Pharmacodynamics of Mycophenolic Acid in Heart Allograft Recipients: Correlation of Lymphocyte Proliferation and Activation With Pharmacokinetics and Graft Histology.” Transplantation, vol. 70, 1038-1049, No. 7, Oct. 15, 2000.
Barten, M. J. et al. “Flow Cytometric Quantitation of Calcium-Dependent and -Independent Mitogen-Stimulation of T cell Functions in Whole Blood: Inhibition by Immunosuppressive Drugs in vitro.” Journal of Immunological Methods 253 (2001) 95-112.
Barten, M. J. et al. “Novel Assays of Multiple Lymphocyte Functions in Whole Blood Measure New Mechanisms of Action of Mycophenolate Mofetil in vivo.” Transplant Immunology 10 (2002) 1-14.
International Search Report prepared by the Australian Patent Office on May 21, 2007, for International Application No. PCT/AU2007/000342; Applicant, St. Vincent's Hospital Sydney Limited.
Endl. et al., “Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes”; Diabetes, vol. 55 (Jan. 2006) pp. 50-60.
Streeter et al., “CD25 expression distinguishes functionally different distinct alloreactive CD4+CD134+(OX40+) T-cell subsets in acute graft-versus-host disease”; Biol. Blood Marrow Transplant (May 2004) vol. 10, No. 5, pp. 298-309.
Nolte-'t et al., “Identification of a CD4+CD25+T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation”; Eur. J Immunol. (2004) vol. 34, pp. 3016-3027.
Zauders et al., “Early proliferation of CCR5+CD38+++antigen-specific CD4+Th1 effector cells during primary HIV-1 infection”; Blood (Sep. 1, 2005) vol. 106, No. 5, pp. 1660-1667.
Giacomelli et al., “T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigent”; Clinical and Experimental Rheumatology (2001) vol. 19, pp. 317-320.
Seddiki et al., “Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells”; JEM (Jul. 2006) vol. 203, No. 7, pp. 1693-1700.
Markert et al., “Choriocarcinoma-induced suppression of lymphocyte activity”; Invest. Allergol. Clin. Immunol. (2000) vol. 10, No. 6, pp. 323-326.
Kelleher Anthony Dominic
Zaunders John James
Sheridan & Ross P.C.
Skelding Zachary
St. Vincent's Hospital Sydney Limited
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