Method for detecting and quantitating nucleic acid impurities in

Details Method for detecting and quantitating nucleic acid impurities in Method for detecting and quantitating nucleic acid impurities in

1996-04-02

1998-10-20

Horlick, Kenneth R.

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-o

435 6, C12Q 168, G01N 3348

Patent

active

058245570

ABSTRACT:
A homogeneous fluorescence-based nucleic acid detection and quantitation system is provided to measure nucleic acid in protein solutions. The process relies on the intercalation of a non-fluorescent dye into a double-stranded nucleic acid helix or single-stranded nucleic acid. The dye fluoresces after intercalation and the intensity is a direct measurement of the amount of nucleic acid present in the sample.

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patent: 5393657 (1995-02-01), Letwin et al.
Goldman et al., Clin. Chem. 37(9), 1523-1525 (1991).
Briggs et al., Anal. Chem. 63, 850-859 (1991).

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