Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Patent
1996-01-19
2000-05-16
Ludlow, Jan
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
436 64, 436161, 530412, 530417, G01N 3002
Patent
active
06063636&
ABSTRACT:
A method is provided for detecting pathological macromolecules in a patient, comprising obtaining body fluid from the patient, pretreating the body fluid, subjecting the pretreated body fluid to size-exclusion chromatography to create an excluded fluid, and analyzing the excluded fluid to detect macromolecules having a predetermined molecular weight. The method also allows for comparing elution spectra with reference spectra of suspect pathologic proteins.
REFERENCES:
patent: 4762617 (1988-08-01), Stevens
Short et al. J.Chromatogr. vol. 323, No. 2 p 418-23 (1985).
Berggard et al. J. Biol. Chem vol. 244 No. 16 p 4299-307 (1969).
Stevens et al. Proc. Natl. Acad. Sci. USA vol. 77 No. 2 p 1144-8 (1980).
Alan Solomon, Light Chains of Human Immunoglobulins, pp. 101-121, Methods In Enzymology, vol. 116.
Fred J. Stevens et al., Pathogenic Potential Of Human Monoclonal Immunoglobulin Light Chains, Apr. 1994, pp. 3034-3038, Proc. Natl. Acad. Sci. USA.
Fred J. Stevens, Analysis Of Protein-Protein Interaction By Simulation of Small-Zone Size Exclusion Chromatography, pp. 1155-1167, Biophysical Journal, vol. 55.
Fred J. Stevens et al., Macromolecular Interactions: Application of Microcomputer-Controlled, High Speed Size-Exclusion Chromatography, pp. 340 pp. 340-348, Liquid and Gas Chromatography, vol. 4 No. 4.
Myatt Elizabeth A.
Solomon Alan
Stevens Fred J.
Alwan Joy A.
Anderson Thomas G.
Ludlow Jan
Moser William R.
The United States of America as represented by the United States
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