Method for detecting amine-containing drugs in body fluids by si

Details Method for detecting amine-containing drugs in body fluids by si Method for detecting amine-containing drugs in body fluids by si

1985-02-05

1990-02-20

Hill, Jr., Robert J.

Chemistry: analytical and immunological testing

Nitrogen containing

Amine and quaternary ammonium

436 96, 436 98, 436111, 436173, G01N 2762

Patent

active

049026275

ABSTRACT:
A method of analyzing a sample for selected molecules which consists of reacting the molecule with a reagent that produces a charged derivative which can be desorbed and analyzed using Secondary Ion Mass Spectrometry (SIMS).

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patent: 4378499 (1983-04-01), Spangler et al.
Hunt et al., Anal. Chem., vol. 50, No. 13, pp. 1781-1784, 1978.
Cooks et al.; Laser Desorption, SIMS, and Oher Forms of Desorption Ionizan ASMS Jun. 1982, pp. 585-590.
Busch et al.; SIMS: Application to Biomolecules ASMS Jun. 1982, pp. 388-389.
Scheifers et al.; Molecular SIMS; American Lab. Mar. 1982, pp. 19-33.
S. E. Unger et al., "Identification of Quartenary Alkaloides in Mushroom by Chromatography/Secondary Ion Mass Spectrometry", Anal. Chem. 1981, 53, 976-981.
Bush and Cooks, Mass Spectrometry of Large, Fragile, and Involatile Molecules, Science, V. 281, 15 Oct. 1982.
Ross, Kidwell, and Colton, Selective Detection of Aldehydes and Ketones by Derivatization/Secondary Ion Mass Spectrometry, 32nd Annual Conference on Mass Spectrometry, San Antonio, Tex., 27 May-1 Jun. 1984.
Kidwell, Ross, and Colton, Sequencing of Peptides by Secondary Ion Mass Secondary Ion Mass Spectrometry, J. Am. Chem. Soc., 2219-2220, 4 Apr. 1984.
K. L. Busch et al., "Desorption Ionization Mass Spectrometry:Sample Preparation for Secondary Ion Mass Spectrometry, Laser Desorption and Field Desorption", J. Am. Chem. Soc., 1982, 104, pp. 1507-1511.

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