Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-04-26
2005-04-26
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S007100, C435S007500, C435S007900, C435S015000, C435S175000, C435S177000, C435S178000, C435S180000, C435S193000, C435S810000, C435S814000, C435S969000, C435S975000, C436S063000, C436S086000, C436S172000, C436S518000, C436S528000, C436S529000, C436S800000, C436S805000, C436S815000, C436S823000
Reexamination Certificate
active
06884597
ABSTRACT:
A method for simply and conveniently detecting acetyltransferase and deacetylase activities of proteins by executing an acetylation reaction of a peptide substrate with an acetyltransferase, or a deacetylation reaction of an acetylated peptide substrate with a deacetylase, and after the completion of these reactions, detecting the acetyl group bound to the peptide substrate by using an anti-acetylated peptide antibody. This system for detecting acetyltransferase and deacetylase activities using the anti-acetylated peptide antibody enables screening inhibitors or enhancers of acetyltransferase and deacetylase. A system for screening deacetylase inhibitors or acetyltransferase enhancers using cultured cells is also provided.
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Miyazaki Toshiaki
Tamai Katsuyuki
Taya Yoichi
Corless Peter F.
Edwards & Angell LLP
Le Long V.
Medical & Biological Laboratories Co. Ltd.
O'Day Christine C.
LandOfFree
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