Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-09-22
1996-12-31
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 2433, 536 232, 435 912, C12Q 168, C07H 2104, C12P 1934
Patent
active
055893317
ABSTRACT:
A method of detecting abnormal serotonergic function in an impulsive human subject is disclosed. The method comprises detecting an L allele of a gene encoding tryptophan hydroxylase. The invention also includes an isolated nucleic acid having a sequence specific to an L allele of a gene encoding tryptophan hydroxylase. The nucleic acid may migrate in a denaturing gel at the same rate as a second nucleic acid specific to a corresponding region of a U allele of a gene encoding tryptophan hydroxylase, and migrate in a nondenaturing gel at a rate about 1.02 times the migration rate of the second nucleic acid.
REFERENCES:
Nielsen et al., Am J. Hum. Genet. 51(6): 1366-1371 (Dec. 1992).
Ainsworth et al., "Diagnostic single strand conformational polymorphism, (SSCP): a simplified non-radioisotopic method as applied to a Tay-Sachs B1 variant," Nucleic Acids Research, 19(2): 405-406 (1991).
Arato et al., "Serotonin dysregulation in suicide," Royal Society of Medicine Services International Congress and Symposium, Series No. 165, pp. 41-46 (1991).
Asberg et al., "5-HIAA in the Cerebrospinal Fluid," Arch Gen Psychiatry, 33: 1193-1197 (1976).
Ballenger et al., "Alcohol and Central Serotonin Metabolism in Man," Arch Gen Psychiatry, 36:224-227 (1979).
Boularand et al., "Complete coding sequence of human tryptophan hydroxylase," Nucleic Acids Research, 18 (14): 4257 (1990).
Craig et al., "Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.5.fwdarw.p14 by in situ hybridization," Cytoenetics and Cell Genetics, 56 (3-4):157-159 (1991).
Grenett et al., "Full-length cDNA for rabbit tryptophan hydroxylase: Functional domains and evoluation of Aromatic Amino acid hydroxylases," Proc. natl. Acad. Sci. USA, 84:5530-5534 (1987).
Kim et al., "Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons," Molecular Brain Research, 9:277-283 (1991).
Kovar et al., "Two dimensional single-strand conformation polymorphism analysis: a useful tool for the detection of mutations in long DNA fragments," Nucleic Acids Research, 19 (13): 3507-3510 (1991).
Roy et al., "Cerebrospinal fluid monoamine metabolites in alcoholic patients who attempt suicide," Acta Psychiatr Scand, 81:58-61 (1989).
Lester, "Biochemical correlates of suicidal behavior in arsonists, " Psychological Reports, 64:258 (1989).
Linnoila et al., "Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior," Life Sciences, 33:2609-2614 (1983).
Lopez-Ibor Jr., et al., "Serotonin, impulsiveness and aggression in humans," Royal Society of Medicine Services International Congress and Symposium, Series No. 165, pp. 35-40 (1991).
Mann et al., "Increased Serotonin.sub.2 and .beta.-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims," Arch Gen Psychiatry, 43:954-959 (1986).
Oreland et al., "Platelet MAO Activity and Monoamine Metabolites in Cerebrospinal Fluid in Depressed and Suicidal Patients and in Healthy Controls," Psychiatry Research, 4: 21-29 (1981).
Orita et al., "Rapid and Sensitive Detection of Point Mutations and DNA Polymorphisms Using the Polymerase Chain Reaction," Genomics, 5:874-879 (1989).
Woodcock in Restak, ed. "A Neuropsychiatric Approach to Impulse Disorders," Psychiatric Clinics of North America, 9 (2): 341-352 (1986).
Roy et al., "Serotonin in Suicide, Violence, and Alcoholism," Serotonin in Major Psychiatric Disorders, pp. 187-208 (1990) Cocaro et al. ed.
Soubrie et al., "Reconciling the role of central serotonin neurons in human and animal behavior," The Behavioral and Brain Sciences, 9 (2):319-364 (1986).
Stoll et al., "Isolation and Structural Characterization of the Murine Tryptophan Hydroxylase Gene," Journal of Neuroscience Research, 28:457-465 (1991).
Traskman et al., "Monoamine Metabolites in CSF and Suicidal Behavior," Arch Gen Psychiatry, 38:631-636 (1981).
Virkkunen et al., "Cerebrospinal Fluid Monoamine Metabolite Levels in Male Arsonists," Arch Gen Psychiatry, 44:241-247 (1987).
Goldman David
Linnoila Markku
Nielsen David A.
Virkkunen Matti
The United States of America as represented by the Department of
Zitomer Stephanie W.
LandOfFree
Method for detecting abnormal serotonergic function does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for detecting abnormal serotonergic function, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detecting abnormal serotonergic function will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1141204