Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-06
1998-12-01
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 254, 530412, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C07H 2102
Patent
active
058436537
ABSTRACT:
This invention discloses a method of detecting the presence or absence of a target molecule in a sample and a method of measuring the amount of a target molecule in a sample using nucleic acid ligands. In a preferred embodiment the nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential Enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis
patent: 4935363 (1990-06-01), Brown et al.
patent: 5070010 (1991-12-01), Hsu
patent: 5270163 (1993-12-01), Gold et al.
Kadonaba et al., PNAS, USA 83:5889-5893 (Aug. 1986).
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Levisohn and Spiegelman (1968) Proc. Natl. Acad. Sci. USA 60:866.
Orgel (1979) Proc. R. Soc. Lon. B205:435.
Kramer et al. (1974) J. Mole. Biol. 89:719.
Joyce (1989) Gene 82:83.
Joyce and Inoue (1989) Nucleic Acids Research 17:711.
Ellington and Szostak (1990) Abstract, May 16-20 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 226.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
Oliphant et al. (1989) Molecular and Cellulary Biology 9:2944.
Oliphant and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Robertson and Joyce (1990) Nature 344:467.
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.
Andrake (1988) Proc. Natl. Acad. Sci. USA 85:7942.
Carey et al. (1983) Biochem. 22(11):2601.
Cohen et al. (1969) Proc. Natl. Acad. Sci. USA 63:458.
Joyce (1989) RNA: Catalysis, Splicing . . . , Belfort et al., eds. Elsevier, p. 83.
Kacian et al. (1972)Proc. Natl. Acad. Sci. USA 69:3038.
Kinzler et al. (1990) Mol. Cell. Biol. 10(2):634.
Lestienne et al. (1983) Biochime. 65:49.
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Ma and Ptashne (1987) Cell 51:113.
Maniatis (1982) Molecular Cloning: a laboratory manual. Cold Spring Harbor, NY p. 118.
Maniatis et al. (1987) Science 236:1237.
Miele et al. (1983) J. Mol. Biol. 171:281.
Mills et al. (1967) Proc. Natl. Acad. Sci. USA 58:217.
Mills et al (1973) Science 180:916.
Min et al (1988) Nucleic Acids Res. 16:5075.
Muesing et al. (1985) Nature 313:450.
Oliphant et al. (1990) Molecular and Cellular Biology 9:2944.
Ou et al. (1988) Science 239:295.
Romaniuk et al. (1987) Biochem. 26(6):1563.
Saffhill et al. (1970) J. Mol. Biol. 51:531.
Sambrook et al. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Section 8.9-8.10.
Uhlenbeck et al. (1983) J. Biomolecular Structure and Dynamics 1:539.
Watson et al (1987) Molecular Biology of the Gene. Benjamin/Cummings Publishing Co., Inc. California, pp. 267,295,323,361,394,396,397 and 405.
Gold Larry
Tuerk Craig
NeXstar Pharmaceuticals, Inc.
Zitomer Stephanie W.
LandOfFree
Method for detecting a target molecule in a sample using a nucle does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for detecting a target molecule in a sample using a nucle, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detecting a target molecule in a sample using a nucle will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2394535