Method for detecting a propensity of an individual to...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C536S023100, C536S023500, C536S024310

Reexamination Certificate

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07108978

ABSTRACT:
It is provided isolated polynucleotides that include sequences from genomic region around the gene CD 81. The polynucleotides include polymorphisms associated with treatment response of HCV patients to interferon-α and ribavirin combined therapy and are useful as the probes in screening for patients who will response to interferon-α and ribavirin combined therapy. It is further provided linkage disequilibrium structure of the CD81 gene and haplotype information within a particular LD block, which can be used for prediction of the treatment outcome of the interferon-α and ribavirin combined therapy on HCV patients.

REFERENCES:
Kerr et al. Arthritis and Rheumatism, Sep. 1999. 42(9 Supplement) S336, Abstract 1591.
Hennig et al. Genes and Immunity. 2002. 3: 359-367.

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