Method for detecting a progressive, chronic dementia...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C436S516000, C436S169000, C436S536000, C530S305000

Reexamination Certificate

active

10476976

ABSTRACT:
The invention relates to defined peptides and the quantitative determination thereof in body fluids of patients suffering from progredient chronic dementia, in relation to the concentration of said peptides in a control group. The inventive peptides come from a protein precursor having the corresponding gene, are processed in a specific manner, and are optionally post-translationally modified, especially phosphorylized. An increase in the concentrations of these peptides or the corresponding non-processed protein indicates progredient chronic dementia. Progredient chronic dementia is detected by identifying the peptides and/or the protein individually or in combinations. The invention also relates to the use of said peptides for controlling the course of progredient chronic dementia and for the prognosis of progredient chronic dementia, especially for complementing or replacing mini-mental scores, and for developing therapeutic agents to combat progredient chronic dementia such as Alzheimer's disease.

REFERENCES:
patent: WO98/08379 (1996-08-01), None
patent: WO00/63241 (1999-04-01), None
patent: WO01/71358 (2001-03-01), None
patent: WO01/75165 (2001-03-01), None
patent: WO02/081522 (2002-04-01), None
patent: WO02/092122 (2002-05-01), None
Butler W. T. Connect Tissue Res. 1989;23(2-3):123-36.
Stark et al. J. Chromat. B. 2001: 357-367.
Keifer, et al.; The CDNA and derived amino acid sequences for human osteopontin Nucleic Acids Research, Oxford University Press; ?Surrey GB; vol. 17 No. 8, 1989 p. 3306.
Oral Health Sciences Unit Projects; School of Dental Science; Faculty of Science, Faculty of Medicine, Dentistry and Health Sciences; Sep. 2000; L. Huq, et al. The University of Melbourne.

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