Method for detecting a predisposition to susceptibility to toxic

Details Method for detecting a predisposition to susceptibility to toxic Method for detecting a predisposition to susceptibility to toxic

1997-08-05

1999-08-10

Houtteman, Scott W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 2431, C12Q 168

Patent

active

059357908

ABSTRACT:
The present invention relates to methods for diagnosis of susceptibility to neurotoxicity or the pathological effects of neurotoxicity based on detection of a genetic marker in an individual. The present invention is directed generally to methods and associated compositions and kits for detecting the presence of arylsulfatase A (ASA) pseudodeficiency (PD) mutations in humans. Detection of these mutations has been surprisingly found to be a strong indicator for susceptibility to neurotoxicity and/or susceptibility to toxicant's pathological effects, as well as an important marker in evaluating the likelihood of metachromatic leukodystrophy (MLD).

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