Method for detecting a pericentric inversion in a chromosome

Details Method for detecting a pericentric inversion in a chromosome Method for detecting a pericentric inversion in a chromosome

1999-05-04

2000-10-31

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436 94, 536 243, 536 2431, C12Q 168, C07H 2104

Patent

active

061400572

ABSTRACT:
A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.

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patent: 5817462 (1998-10-01), Garini et al.
patent: 5936731 (1999-08-01), Cabib et al.
Lucas et al., Inc. J. Radiat. Biol. 71(1), 29-33 (Jan. 1997).

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