Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-10-24
1997-11-25
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 2, 436501, 436542, 436545, 436546, 436548, 436 56, 436 57, 436 63, 436172, 436805, 436811, 53038822, 5303887, 424 9373, 424533, C01N 33532
Patent
active
056911572
ABSTRACT:
The present invention is directed to a method for detecting a mammal's prior exposure to radiation or radiomimetic agents. Labeled antibodies are employed to determine the quantity of transferrin receptors on the red blood cells of the mammal. The quantity of transferrin receptors on the red blood cells of the mammal is correlated to the mammal's prior exposure.
REFERENCES:
patent: 4497547 (1985-02-01), Allen et al.
patent: 4752582 (1988-06-01), Vanderlaan et al.
patent: 4752583 (1988-06-01), Jensen et al.
patent: 4767710 (1988-08-01), Bigbee et al.
patent: 5352432 (1994-10-01), Meny et al.
Gorbenko et al. "Influence of radiation of the . . ." 1995 Institute of Cryobiology and Cyomedicine Problems Ukranian Acad. Sci.
Biosis An 87:148473, Chifambar et al. "Inhibition of Hemoglobin . . . " 1987.
Embase An 94036696, Fujiwara et al. "Autoantibodies and . . . " 1994.
Biosis An 93:322048, Perera et al. "HPRT and Glycophorin A . . . " 1993.
Biosis An 96:158007, Mitsatis "Transgenic Models for detection . . . " 1995.
Gong et al., "A Method for Determining Residual Injury in the Hematopoietic System of the X-Irradiated Rat," Radiation Research 37(3):467-477 (1969).
Gong et al., "Effects of Low-Level (1.0 R) X-Irradiation on the Erythroid Response of the Rat Bone Marrow," Radiation Research 65:83-97 (1976).
Lawson et al., "Recurrent Decreases of Erythrocyte Electrophoretic Mobility in Rats Exposed to 1.0 R Whole-Body X-Radiation," Cell Biophysics 4:47-61 (1982).
Gong et al., "The Effects of Low Dose (Less than 1 Rad) X-Rays on the Erythropoietic Marrow," Cell Biophysics 5:143-162 (1983).
Langlois et al.,"Measurements of the Frequency of Human Erythrocytes with Gene Expression Loss Phenotypes at the Glycophorin A Locus," Hum. Genet. 74:353-362 (1986).
Langlois et al., "Evidence for Increased Somatic Cell Mutations at the Glycophorin A Locus in Atomic Bomb Survirors," Science 236:445-448 (1987).
Gong et al., "Iron Kinetics Effects of 88 Millirads: Partial-versus-Total Body X-Irradiation," Cell Biophysics 13:15-27 (1988).
Akiyama et al., "Evaluation of Four Somatic Mutation Assays as Biological Dosimeter in Humans," in Radiation Research: A Twentieth-Century Perspective, Dewey, et al., eds, vol. II Congress Proceedings, New York: Academic Press, pp. 77-182 (1992).
Jensen et al., "Biodosimetry of Ionizing Radiation in Humans Using Glycophorin A Genotoxicity Assay," Radiation Research: A Twentieth-Century Perspective, Dewey et al.,eds, vol. II Congress Proceedings, New York:Academic Press pp. 172-176 (1992).
Langlois et al., "Analysis of Somatic Cell Mutations at the Glycophorin A Locus in Atomic Bomb Survivors: A Comparative Study of Assay Methods," Radiation Research 136:111-117 (1993).
Glomski Chester A.
Gong Joseph K.
Freed Rachel Heather
Hutzell Paula K.
The Research Foundation of State University of New York
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