Surgery – Miscellaneous – Methods
Patent
1998-01-28
2000-10-31
Ungar, Susan
Surgery
Miscellaneous
Methods
514 2, 514 8, 514 12, 514 21, 514 23, A61B 1900, A01N 3718, A01N 3800, A01N 4304
Patent
active
061386804
ABSTRACT:
A method for destroying retinal pigment epithelial cells in an eye in order to prevent the occurrence of proliferative vitreoretinopathy. A solution containing a basement membrane binding agent conjugated to a cytotoxic agent is introduced into the vitreous chamber. The solution is maintained in the vitreous chamber for a period of time sufficient to permit the basement membrane binding agent to bind to basement membranes lining the vitreous chamber. The solution is then removed from the vitreous chamber, whereby a portion of the basement membrane binding agent remains bonded to basement membranes within the vitreous chamber, thereby exposing retinal pigment epithelial cells disposed on the basement membrane to the cytotoxic agent.
REFERENCES:
patent: 4920104 (1990-04-01), DeVore et al.
Nagasaki et al (Progress in Retinal and Eye Res., 17:77-98), 1998.
Handa et al (Current Eye Res., 15:1039-1044), 1996.
Burgess et al (J. Cell Bio., 111:2129-2138), 1990.
Bausch & Lomb Surgical, Inc.
Ungar Susan
Vacca Rita D.
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