Method for destroying residual lens epithelial cells

Surgery – Miscellaneous – Methods

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514 2, 514 8, 514 12, 514 21, 514 23, A61B 1900

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06089234&

ABSTRACT:
A method for destroying residual lens epithelial cells in an eye in order to prevent the occurrence of posterior chamber opacification. A solution containing a basement membrane binding agent conjugated to a cytotoxic agent is introduced into the lens capsule. The solution is maintained in the lens capsule for a period of time sufficient to permit the basement membrane binding agent to bind to basement membranes within the lens capsule. The solution is then removed from the lens capsule, whereby a portion of the basement membrane binding agent remains bonded to basement membranes within the lens capsule, thereby exposing residual lens epithelial cells disposed on the basement membrane to the cytotoxic agent.

REFERENCES:
patent: 4432751 (1984-02-01), Emery et al.
patent: 4515794 (1985-05-01), Emery et al.
patent: 4657930 (1987-04-01), Emery et al.
patent: 4847240 (1989-07-01), Ryser et al.
patent: 4871350 (1989-10-01), Lam et al.
patent: 4918165 (1990-04-01), Soll et al.
patent: 5055291 (1991-10-01), Lam et al.
patent: 5202252 (1993-04-01), Emery et al.
patent: 5273751 (1993-12-01), Dubroff
patent: 5375611 (1994-12-01), Lindqvist et al.
patent: 5620013 (1997-04-01), Bretton
"Biphasic Effect of the Mitotoxin bFGF-Saporin on Bovine Lens Epithelial Cell Growth: Effect of Cell Density and Extracellular Matrix", Thierry David, Jacqueline Tassin, Douglas A. Lappi, Andrew Baird, Yves Courtoies, Journal of Cellular Physiology, 1992, pp. 483-490.
"Inhibition of Proliferating Lens Epithelium with Antitransferrin Receptor Immunotoxin", Kenneth M. Goins, MD; Julio R. Ortiz, MD; Sam F.A. Fulcher, MD; Janes T. Handa, MD; Glenn J. Jaffe, MD; Gary N. Foulks, MD; L. Michael Cobo, MD; J. Cararact Refract Surg, vol. 20, Sept. 1994, pp.513-516.
"Merck Manual", Fifteenth Ed., Merck & Co., Rahway, NJ, 1987, pp. 1120-1121.
Hardten "The Cornea in Cataract and Intraocular Lens Surgery" Current Opinion in Opthalmology 8;1:33-38, 1997.

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