Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-07-02
1999-08-31
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3140
Patent
active
059454393
ABSTRACT:
This invention is a process for the use of a combination of ionizing radiation in conjunction with certain benzoporphyrin derivative compounds (BPD), preferably the compound benzoporphyrin derivative-monoacid ring-A (BPD-MA), to mediate the destruction of diseased or unwanted cells or tissues. Specifically, the invention is a method in which the sensitizer compounds are administered either systemically or locally to the diseased or unwanted tissue and irradiated with ionizing radiation (such as might be produced by a .sup.60 Co or x-ray source). The treatment with benzoporphyrin derivative compounds appears to sensitize the target cells or tissues in that those cells do not readily recover from irradiation exposure. In addition, the process may be used to lower the effective amount of radiation applied to a particular tissue target.
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Dolphin David
Levy Julia G.
Richter Anna
QLT PhotoTherapeutics, Inc.
Raymond Richard L.
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