Method for destroying microbial contamination in protein materia

Chemistry: electrical and wave energy – Processes and products – Processes of treating materials by wave energy

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422 22, 422 23, 422 24, 424101, 514 2, C07G 700, A61L 200, A61K 4100, B01J 1908

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active

046209085

ABSTRACT:
A method for destroying microbial contamination, such as viral and bacterial contamination and mycoplasma contamination, in protein material, and particularly tissue and serum from animals and human beings. The method comprises the reducing of the temperature of the protein material, in a state other than a lyophilized state, to at least the freezing point and preferably to the eutectic point. The method comprises reducing the temperature of lyophilized protein to at least a temperature of -3 degrees C., or colder. Thereafter, gamma radiation is applied in an amount sufficient, at least 5,000 rads and preferably at least 600,000 rads, to destroy substantially all microbial contamination in the protein material without significantly reducing the protein efficacy.

REFERENCES:
patent: Re23195 (1950-02-01), Brasch
patent: 3743480 (1973-07-01), Falk
patent: 3779706 (1973-12-01), Nablo
patent: 4136094 (1979-01-01), Condie
patent: 4251437 (1981-02-01), Rasmussen et al.
patent: 4330626 (1982-05-01), Blair et al.
patent: 4370264 (1983-01-01), Kotitschke et al.

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