Method for depletion of glutathione

Details Method for depletion of glutathione Method for depletion of glutathione

1995-01-13

1995-12-19

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 13, 560125, 560149, 560150, 562430, C07C 6108

Patent

active

054769663

ABSTRACT:
This invention relates to certain S-substituted homocysteine sulfoximines and their uses. Buthionine sulfoximine (BSO) appears to have significant uses for chemotherapy and radio therapy, especially combination chemotherapy and radiation therapy and for treatment of subjects with parasitic infections. The compounds of the invention have the same above-mentioned utilities as BSO but have one or more superior attributes when compared to BSO.

REFERENCES:
Griffith, J. Biol. Chem., 254, pp. 7558-7560 (1979).
Meister, Current Topics in Cellular Regulation, 26, pp. 383-394 (1985).
Seelig, Methods in Enzymology, 113, pp. 379-390 (1985).
1988 FASEB Abstract.
Griffith et al, J. Biological Chem., 1979, 254:1205-1210.
Meister et al, Cancer Treat. Reports, 1979, 63:1115-1121.
Griffith, J. Biological Chem., 1982, 257:13704-13712.
Dethmers et al, Proc. Nat'l Acad. Sci. USA, 1981, 78:7492-7496.
Meister, Science, 1983, 220:472-477.
Meister, Hepatology, 1984, 4:739-742.
Griffith et al, Proc. Nat'l Acad. Sci. USA, 1985, 82:4668-4672.
Meister, Nutritional Rev., 1984, 42:397-410.
Anderson, Methods in Enzymology, 1985, 113:548-555.

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