Method for delivery of smooth muscle cell inhibitors

Details Method for delivery of smooth muscle cell inhibitors Method for delivery of smooth muscle cell inhibitors

1991-02-28

1992-12-15

Yasko, John D.

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

604269, 128898, A61M 3100

Patent

active

051712172

ABSTRACT:
A method and composition for delivering a drug to an affected intramural site for sustained release in conjunction with or following balloon catheter procedures, such as angioplasty. The drug, carried by microparticles of a physiologically-compatible, biodegradable polymer is injected under directed pressure into the wall of a body vessel in the region of the affected site.

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Use of a Perforated Balloon Catheter to Deliver Concentrated Heparin into the Wall of the Normal Canine Artery, Wolinsky et al., J. Am. Coll. Cardiol., 15:475 (1990).
Local Anticoagulation Without Systemic Effect Using a Polymer Heparin Delivery System, Okada et al., Stroke 19:1470 (1988).
Effect of Controlled Adventitial Heparin Delivery on Smooth Muscle Cell Proliferation Following Endothelial Injury, Edelman, Proc. Natl. Acad. Sci. U.S.A. 87:3773 (1990).
Laser Balloon Angioplasty: Potential for Reduction of the Thrombogenicity of the Injured Arterial Wall and for Local Application of Bioprotective Materials, Spears et al., unpublished paper presented and copies distributed at the Fourth Annual International Workshop on the Future Direction of Interventional Cardiology, Sep. 7-8, 1990, Santa Barbara, Calif.

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