Method for delivery of nucleic acids to cells using hypericin po

Details Method for delivery of nucleic acids to cells using hypericin po Method for delivery of nucleic acids to cells using hypericin po

1994-09-02

1998-10-20

Campell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4351721, 4351723, 4352401, 530324, 536 231, 552282, 935 52, A61K 4800, C09B 340, C12N 500

Patent

active

058246541

ABSTRACT:
The invention provides improved methods for delivery of nucleic acids to cells, which comprise forming ternary complexes between a hydrophobic, membrane-binding anion such as hypericin; a polycation such as polylysine; and a nucleic acid such as DNA; and contacting cells with the tenary complexes. Also provided are pharmaceutical formulations comprising these ternary complexes and a pharmaceutically acceptable carrier or diluent. The methods and compositions find use in mediating DNA uptake into cells, including gene therapy applications.

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