Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-06-06
1999-08-24
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424426, 424430, 424434, 424435, 424436, 424451, 424464, A61K 950, A61K 948, A61F 202, A61F 902
Patent
active
059422521
ABSTRACT:
A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective amounts of the microcapsules to the animal. A pulsatile response is obtained, as well as mucosal and systemic immunity.
REFERENCES:
patent: 2738303 (1956-03-01), Blythe
patent: 3474777 (1969-10-01), Figge et al.
patent: 3823228 (1974-07-01), Ferris et al.
patent: 3887699 (1975-06-01), Yolles
patent: 3959457 (1976-05-01), Speaker et al.
patent: 4021364 (1977-05-01), Speiser et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4123519 (1978-10-01), Tribble et al.
patent: 4148876 (1979-04-01), Almeida et al.
patent: 4152413 (1979-05-01), Goodnow
patent: 4152414 (1979-05-01), Harris et al.
patent: 4152415 (1979-05-01), Harris et al.
patent: 4166800 (1979-09-01), Fong
patent: 4196188 (1980-04-01), Besins
patent: 4203968 (1980-05-01), Harris et al.
patent: 4209507 (1980-06-01), Ogino et al.
patent: 4269821 (1981-05-01), Kreuter et al.
patent: 4291016 (1981-09-01), Nougaret
patent: 4292298 (1981-09-01), Davis
patent: 4298002 (1981-11-01), Ronel et al.
patent: 4309405 (1982-01-01), Guley et al.
patent: 4309406 (1982-01-01), Guley et al.
patent: 4326524 (1982-04-01), Drake, Jr. et al.
patent: 4349530 (1982-09-01), Royer
patent: 4367217 (1983-01-01), Gruber et al.
patent: 4384975 (1983-05-01), Fong
patent: 4389330 (1983-06-01), Tice et al.
patent: 4428925 (1984-01-01), Keith
patent: 4428926 (1984-01-01), Keith
patent: 4434153 (1984-02-01), Urquhart et al.
patent: 4439199 (1984-03-01), Amkraut et al.
patent: 4455142 (1984-06-01), Martins et al.
patent: 4479911 (1984-10-01), Fong
patent: 4484923 (1984-11-01), Amkraut et al.
patent: 4524060 (1985-06-01), Mughal et al.
patent: 4525339 (1985-06-01), Behl et al.
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4530840 (1985-07-01), Tice et al.
patent: 4542025 (1985-09-01), Tice et al.
patent: 4559303 (1985-12-01), Aotani et al.
patent: 4585651 (1986-04-01), Beck et al.
patent: 4590170 (1986-05-01), Akiyoshi et al.
patent: 4610870 (1986-09-01), Jain et al.
patent: 4613500 (1986-09-01), Suzuki et al.
patent: 4650769 (1987-03-01), Kakimi et al.
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4681752 (1987-07-01), Melillo
patent: 4690682 (1987-09-01), Lim
patent: 4732763 (1988-03-01), Beck et al.
patent: 4764359 (1988-08-01), Lemelson
patent: 4783336 (1988-11-01), Margel et al.
patent: 4845042 (1989-07-01), Newman et al.
patent: 4919929 (1990-04-01), Beck
patent: 4925673 (1990-05-01), Steiner et al.
patent: 4990336 (1991-02-01), Silvestri et al.
patent: 5075109 (1991-12-01), Tice et al.
patent: 5126147 (1992-06-01), Silvestri et al.
patent: 5382435 (1995-01-01), Geary et al.
patent: 5384133 (1995-01-01), Boyes et al.
patent: 5417986 (1995-05-01), Reid et al.
patent: 5503841 (1996-04-01), Doyle et al.
Schroeder & St.ang.hl, J. Immunol. Methods 70, 127-132 (1984).
"Biomedical Applications of Microencapsulation", Ed. F. Lim, Chapter 3, pp. 53-58, CRC Press, Boca Raton, FL. (1984).
Langer "Polymers for Release of Macromolecules", Chapter 4 (pp. 57-75) in Methods in Enzymol. vol. 73, "Immunochemical Techniques", Ed. Langone & Van Vunakis (1981).
Eldridge et al, "New Strategies for Oral Administration", Birmingham, Alabama as reported in "Current Topics in Microbiology and Immunology", 146, 59-66, (1989) (Received by the University of Alabama at Birmingham Library on Jun. 12, 1989).
Moldoveanu et al., "New Stragegies for Oral Administration", Birmingham Alabama, as reported in "Current Topics Microbiol. Immunol." 146, 91-99, (1989) (Received by the University of Alabama at Birmingham Library on Jun. 12, 1989).
Artursson et al., "Characterization of Polyacryl Starch Microparticles as Carriers for Proteins and Drugs," J.Pharm.Sci., vol. 73, No. 11, pp. 1507-1513 (Nov. 1984).
Artursson et al., "Biodegradable Microspheres II: Immune Response to a Heterologous and an Autologous Protein Entrapped in Polyacryl Starch Microparticles," J.Pharm.&Exp.Ther., vol. 234, No. 1, pp. 255-260 (1985).
Artursson et al., Biochemical and Cellular Effects of Degraded Starch Microspheres on Macrophages, Intl.J.Pharm., vol. 52, pp. 183-190 (1989).
Barratt et al., "Delivery of MDP-L-alanyl-cholesterol to Macrophages: Comparison of Liposomes and Nanocapsules," The Cancer Journal, vol. 2, No. 12, pp. 439-443 (Nov./Dec. 1989).
Chang, T., "Biodegradable Semipermeable Microcapsules Containing Enzymes, Hormones, Vaccines, and Other Biologicals," J.Bioeng., vol. 1, pp. 25-32 (1976).
Cox et al., "Oral Induction of the Secretory Antibody Response by Soluble and Particulate Antigens," Int.Archs.AllergyAppl.Immun., vol. 75, pp. 126-131 (1984).
Damge et al., "New Approach for Oral Administration of Insulin with Polyalkylcyanoacrylate Nanocapsules as Drug Carrier," Diabetes, vol. 37, pp. 246-251 (Feb. 1988).
DeLuca et al., "Porous Biodegradable Microspheres for Parenteral Administration," Topics Pharm.Sci. 1987, D. Breimer et al., eds., pp. 429-442 (Aug./Sep. 1987).
Gundel et al., "Antigen-Coated Sepharose Beads Induce Airway Eosinophilia and Airway Hyperesponsiveness in Cynomolgus Moneys," Am.Rev.Respir.Dis., vol. 140, pp. 629-633 (1989).
Harmia et al., "Nanoparticles as Drug Carriers in Opthalmology," Pharm.Acta.Helv., vol. 62, No. 12, pp. 322-331 (1987).
Harmsen et al., "The Role of Macrophages in Particle Translocation from Lungs to Lymph Nodes," Science, vol. 230, No. 4731, pp. 1277-1281 (Dec. 1985).
Hay et al., "The Use of Radioactive Microspheres to Quantitate Hyperemia in Dermal Inflammatory Sites," Proceedings of the Society for Experimental Biology and Medicine, vol. 150, pp. 641-644 (Oct.-Dec. 1975).
Hill et al., "Cell-Mediated Immunity to Soluble and Particulate Inhaled Antigens," Chem.Exp.Immunol., Blackwell Scientific Publications, vol. 38, pp. 332-341 (1979).
Illum et al., "Bioadhesive Microspheres as a Potential Nasal Drug Delivery System," Int.J.Pharm., vol. 39 pp. 189-199 (1987).
Juliano et al., "The Effect of Particle Size and Charge on the Clearance Rates of Liposomes and Liposome Encapsulated Drugs," Biochem.&Biophys.Res.Comm., P. Boyer et al., eds., vol. 63, No. 3, pp. 651-659 (1975).
Kanke et al., "Interaction of Microspheres with Blood Constituents and the Effect on Immune Response," Expo-Congr.Int.Technol.Pharm.3d., vol. 4, pp. 162-169 (1983).
Kanke et al., "Interaction of Microspheres with Blood Constituents II: Uptake of Biodegradable Particles by Macrophages," J.Parenteral Sci.&Tech., vol. 40, No. 4, pp. 114-118 (Jul./Aug. 1986).
Kanke et al., "Interaction of Microspheres with Blood Constituents III: Macrophage Phagocytosis of Various Types of Polymeric Drug Carriers," J.Parenteral Sci.&Tech., vol. 42, No. 5, pp. 157-165 (Sep./Oct. 1988).
Klipstein et al., "Peroral Immunizaion of Rats with Escherichia coli Heat Labile Enterotoxin Delivered by Microspheres, Infection and Immunity," vol. 39, No. 2, pp. 1000-1003 (Jan. 1983).
Langenback et al., "Supramicron-sized Particle Clearance from Alveoli: Route and Kinetics," Amer.Physio.Soc.,, pp. 1302-1308 (1990).
LeFevre et al., "Intestinal Barrier to Large Particulates in Mice," J.Toxic.&Envir.Health, vol. 6, pp. 691-704 (1980).
LeFevre et al., "Accumulation of Latex in Peyer's Patches and Its Subsequent Appearance in Villi and Mesenteric Lymph Nodes," Proceedings of the Society for Experimental Biology & Medicine, vol. 159, pp. 298-302 (1978).
Lehnert et al., "Leukocytic Responses to the Intrapleural Deposition of particles, Particle-Cell Associations, and the Clearance of Particles From the Pleural Space Compartment," J.Toxic.&Envir.Health, vol. 24, pp. 41-66 (1988).
Margel et al., "Polyacrolein Microspheres As a New Tool in Cell Biology,"J.Cell Sci., Grimstone et al., vol. 56, pp. 157-175 (1982).
Moldoveanu et al., "Oral Immunization with Influenza Virus in Biodegradable Microspheres," J.Infect.Dis., vol. 167, pp. 001-007 (Sep. 27, 1992).
Nishimura et al., "Effect of Multiporous Microspheres Derived from Chi
Eldridge John H.
Gilley Richard M.
Staas Jay K.
Tice Thomas R.
Azpuru Carlos A.
Southern Research Institute
The UAB Research Foundation
LandOfFree
Method for delivering bioactive agents into and through the muco does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for delivering bioactive agents into and through the muco, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for delivering bioactive agents into and through the muco will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-464474