Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Stabilized enzymes or enzymes complexed with nonenzyme
Patent
1994-08-05
1998-02-10
Weber, Jon P.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Stabilized enzymes or enzymes complexed with nonenzyme
4241301, 4242831, 514 2, A61K 3854, A61K 39395, A61K 4500, A61K 3800
Patent
active
057166145
ABSTRACT:
A method is disclosed for delivering biologically active agents to a mammalian brain by administering a complex of the biologically active agent with a polycationic carrier coupled to 2-20 eicosapentaenoic acid or docosahexaenoic acid moieties and additional eicosapentaenoic acid or docosahexaenoic acid moieties. The polycationic carrier is poly-lysine, poly-arginine or poly-ornithine of 5-50 amino acid residues. The addition of a targeting moiety selected from tetanus toxin C fragrant, .alpha.-bungarotoxin and nerve growth factor to the complex facilitates delivery of the biologically active agent to glial tissue, or to cortical, cholinergic and adrenergic neurons.
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Katz Robert
Tomoaia-Cotisel Maria
Angres Isaac A.
Molecular/Structural BioTechnologies, Inc.
Weber Jon P.
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