Method for decreasing the formation of scar tissue using a purif

Drug – bio-affecting and body treating compositions – Lymphokine

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435 695, 4352402, 43524023, 4352403, A61K 4505, C12P 2106, C12N 500

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active

053245083

ABSTRACT:
Fibroblast growth in a healing wound, and the consequent formation of scar tissue, may be inhibited by application of a macrophage monokine product, the macrophage monokine having a molecular weight of no more than about 10,000 Dalton. The macrophage monokine appears to be generally effective across species of mammals, and also exhibits the characteristic of stimulating hair growth on skin cells to which it is applied.

REFERENCES:
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Daniel A. Rappolee, et al. entitled Wound Microphages Express TGF- and other Growth Factors in Vivo: Analysis by mRNA Phenotyping, Science, vol. 241, Aug. 5, 1988, pp. 708-712.
Joseph Giangiacomo, M.D. et al. entitled The Effect of Preoperative Subconjunctival Triamcinolone Administration on Glaucoma Filtration in Arch. Ophthalmol, vol. 104, Jun., 1986, pp. 838-841.
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Article by H. Orita et al. entitled Modulation of Fibroblast Proliferation and Transformation by Activated Microphages During Post Operative Peritoneal Reepithelialization-American Journal of Obstretics and Gynecology, vol. 155, pp. 905-911, Oct., 1986.

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