Method for decreasing the foam formation during cultivation...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Process involving micro-organisms of different genera in the...

Reexamination Certificate

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Reexamination Certificate

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07338779

ABSTRACT:
This invention relates to a method for decreasing the foam formation during cultivation of a microorganism and to a method for producing an enhanced amount of a product of interest. The method comprises that the microorganism is modified in such a way that the microorganism does not produce an essential amount of at least one of the proteins, polypeptides or peptides associated with foam formation during cultivation of the unmodified microorganism. In particular the method comprises that the microorganism is modified not to produce an essential amount of amphipathic or hydrophobic proteins, polypeptides or peptides.

REFERENCES:
patent: 96/41882 (1996-12-01), None
patent: 98/22598 (1998-05-01), None
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Spanu et al. “Deletion of HCF-a, a hydrophobin gene of Cladosporium fulvum, does not affect pathogenicity on tomato”. May 1998, vol. 52, No. 5, pp. 323-334.
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Tiina Nakari-Setala et al., Eur. J. Biochem. 235, 1996, pp. 248-255, XP002949769.
Tiina Nakari-Setala et al., Eur. J. Biochem. 248, 1997, pp. 415-423, XP002949768.

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