Method for decreasing LDL-cholesterol concentration and increasi

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

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514456, 514821, 514824, A61K 3578, A61K 3135

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active

058558926

ABSTRACT:
A method of altering the concentration of cholesterol constituents in human blood is provided. A daidzein material is administered to a human to increase the concentration of HDL-cholesterol and to decrease the level of LDL-cholesterol in the blood. The daidzein material may be administered in a pharmaceutical composition, or in a dietary supplement, including soy protein based dietary supplements. Utilization of daidzein to increase the concentration of HDL cholesterol and to decrease the concentration of LDL-cholesterol in the blood reduces the risk of atherosclerosis and vascular disease by providing more health beneficial HDL-cholesterol and reducing the level of atherosclerosis-inducing LDL-cholesterol.

REFERENCES:
patent: 4557927 (1985-12-01), Miyake et al.
patent: 4591600 (1986-05-01), Creuzet et al.
patent: 4841077 (1989-06-01), Ito et al.
patent: 4960908 (1990-10-01), Ito et al.
patent: 5320949 (1994-06-01), Shen
patent: 5352384 (1994-10-01), Shen
patent: 5498631 (1996-03-01), Gorbach et al.
patent: 5516528 (1996-05-01), Hughes et al.
patent: 5589182 (1996-12-01), Tashiro et al.
patent: 5637561 (1997-06-01), Shen et al.
patent: 5637562 (1997-06-01), Shen et al.
patent: 5654011 (1997-08-01), Jackson et al.
patent: 5702752 (1997-12-01), Gugger et al.
The Flavanoids, Advances In Research Since 1980, ed. J.B. Harbone, Chapman and Hall, Chapter 5, pp. 125-209 (1988).
Meta-analysis of the Effects of Soy Protein Intake on Serum Lipids, Anderson, Johnstone, and Cook-Newell, New England J. of Med., vol. 333, No. 5, pp. 276-282 (1995).
Soy Isoflavones Enchance Coronary Vascular Reactivity In Atherosclerotic Female Macaques, Honore, Williams, Anthony and Clarkson, Fertil. Steril, vol. 67, No. 1 pp. 148-154 (Jan. 1997).
Soy Protein and Serum Lipids, Potter, Curr. Opin. Lipidol., vol. 7, No. 4, pp. 260-264 (Aug. 1996).
Control of Serum Lipids With Soy Protein, Erdman, New England J. of Med., vol. 333, No. 5, pp. 313-315 (Aug. 3, 1995).
Kelly, WO 9323069 (Abstract), 1993.
Lui et al., A comparison of pharmacodynamics between daidzeu and solid dispensin of daidzein, 1990.
JP 09255570 (Abstract), 1997.
Overview of Proposed Mechanisms for the Hypochoesterolemic Effect of Soy, Potter, J., Nutr., vol. 125, pp. 606S-611S (1995).
A Review of Phytoestrogens and Their Effects in Relation to Menopausal Symptoms, Knight et al., Australian J. of Nut. and Dietetics, 53:1, pp. 5-11 (1996).
Isoflavones and Hypercholesterolemia in Rats, Sharma, Lipids, vol. 14, pp. 535-540 (1978).
Effect of Legume Seeds on Serum Cholesterol, Nutrition Reviews, vol. 38, No. 4, pp. 159-160 (Apr. 1980).
Phytochemicals & Cardiovascular Disease, A Statement for Healthcare Professionals From the American Heart Association, Howard & Kritchevsky, Circulation, 95:2591-2593, 1997.
Naturally Occurring Non-Steroidal Estrogens of Dietary Orgin, Setchell, Estrogens in the Environment, J. McLachlen, Editor, pp. 69-85, (1992).
Dietary Carbohydrates and Low Cholesterol Diets: Effects of Serum Lipids of Man, Hodges et al., Am. J. Clin. Nutr., vol. 20, No. 2, pp. 196-208 (Feb. 1967).
Review of Clinical Studies on Cholesterol-Lowering Response to Soy Protein, Carroll, J. Am. Dietetic Assoc., vol. 91, No. 7, pp. 820-827 (1991).
Soybean Protein Diet Increases Low Density Lipoprotein Receptor Activity in Mononuclear Cells From Hypercholesterolemic Patients, Lovati, et al., J. Clin. Invest., vol. 80, pp. 1498-1502 (1987).
Phytoestrogen Content of Processed Soybean Products, Murphy, Food Technology pp. 60, 62-64 (Jan. 1982).
Studies on the Mechanism of the Cholesterol Lowering Activity of Soy Proteins, Lovati et al., Nutr. Metab. Cardiovasc. Dis., vol. 1, pp. 18-24 (1991).
Comparison of Actions of Soy Protein & Casein on Metabolism of Plasma Lipoproteins & Cholesterol in Humans, Grundy & Abrams, Am. J. Clin. Nutr., vol. 38, pp. 245-252. (1983).
Reproductive and General Metabolic Effects of Phytoestrogens in Mammals, Kaladas and Hughes, Reproductive Toxicology, vol. 3, pp. 81-89 (1989).
Naturally Occurring Oestrogens in Foods--A Review, Price and Fenwick, Food Additives and Contaminants, vol. 2, No. 2, pp. 73-106 (1985).
Commonly Occurring Plant Flavanoids Have Estrogenic Activity, Miksicek, Molecular Pharmacology, vol. 44 (1), pp. 37-43 (1993).
Estrogenic Soybean Isoflavones and Chronic Disease: Risks and Benefits, Clarkson, Anthony, and Hughes, Trends in Endocrinology and Metabolism, vol. 6(1), pp. 11-16 (1995).
Turnover of Very Low-Density Lipoprotein-Apoprotein B is Increased by Substitution of Soybean Protein for Meat & Dairy Protein in the Diest of Hypercholesterolemic Men, Huff, etal., Am. J. of Clin. Nutr., vol. 39, pp. 888-897 (1984).
Role of Dietary, Phytoestrogens in the Protection Against Cancer and Heart Disease, Wiseman, Biochemical Society Transactions, vol. 25(3), pp. 795-800 (1996).
The Nonhuman Primate Model of the Relationship Between Gonadal Steroids and Coronary Heart Disease, Clarkson, Hughes, and Klein, Progress in Cardivascular Diseases, vol. 38/3, pp. 189-198 (1995).
Environmental Estrogens: Effects on Cholesterol Lowering and Bone in the Overectimized Rat, Dodge, Glasebrook, Magee, Phillips, Sato, Short, and Bryant, J. Sterioid Biochem. and Molec. Biol., vol. 59, No. 2, pp. 155-161 (Oct. 1996).
A Review of the Clinical Effects of Phytoesstrogens, Knight and Eden, Obstetrics and Gynecology, vol. 87, No. 5, pp. 897-904 (May 1996).
SymposiaExamining the Benefits of Dietary Phytoestrogens, Inpharma, Dec. 6, 1996.
A Soy Protein Isolate Rich in Genistein and Daidzein and its Effect on Plasma Isoflavone Concentrations, Platelet Aggregation, Blood Lipids, and Fatty Acid Composition of Plasma Phospholipid in Normal Men, Gooderham, Adlercreutz, Ojala, Wahala, & Holub, J. Nutrition, vol.126/8, pp. 2000-2006 (1996).
Health Relevance of Soya Beans due to their Isoflavonoid Content, Bohm and Frank, Z. Lebensmittelwirtsch, vol. 47, No. 12, pp. 55-57 (1996).
A Comparison of Pharmacodynamics Between Daidzein and Solid Dispersion of Daidzein Liu, Wang, Yan, Han, Zhang, & Cai, Shenyang Yaoxueyuan Xuebao, vol. 7(2), 123-5,131. 1990.
A Review of Phytoestrogens and Their Effects in Relation to Menopausal Symptoms, Knight, Lyons, and Eden, Aust. J. Nutr. Diet., vol. 53(1), pp. 5-11 (1996).
Modern Uses For An Ancient Bean: Soyfoods and Disease, Messina, Chem. Ind. vol. 11, pp. 412-415 (1995).
Soybean Isoflavones Improve Cardiovascular Risk Factor Without Affecting the Reproductive System of Peripubertal Rehesus Monkeys, Anthony, Clarkson, (1996).
Hughes, Morgan and Burke, J. Nutr., vol. 126, No. 1, pp. 43-50 (Jan. 1996). Oxidized Low Density Lipoprotein-Mediated Activation of Phospholipase D in Smooth Muscle Cells: A Possible Role in Cell Proliferation and Atherogenisis, Natarajan, Scribner, Hart & Parthasarathy, J. Lipd Res.
Thrombotic Mechanisms in Atherosclerosis: Potential Impact of Soy Protein, Wilcox & Blumenthal, J. Nutr., vol. 125, Supp. 3, pp. 631s-638s (Mar. 1995).
Biology of Atherosclerotic Plaque Formation: Possible Role of Growth Factors in Lesion Development and the Potential Impact of Soy, Raines and Ross, J. Nutr. vol. 125, Supp. 3, pp. 624s-630s (Mar. 1995).
Soy In The Spotlight, Kuhn, Food Process., vol. 57, No. 5, pp. 52-58 (1996) .

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