Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-05-21
1995-10-17
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 11, 514642, 514743, 514 12, 514 21, A61K 3700, A61K 3114, A61K 3102
Patent
active
054591260
ABSTRACT:
A method for reducing calcium overload in cells to prevent the transition from reversible to irreversible injury. The cell surface is treated with an organic polycation selected from the group consisting of protamine, dodecyltrimethylammonium bromide, polymyxin B sulfate and polybrene which is capable of altering the cells surface charge sufficiently to eliminate or reduce the influx of calcium resulting from exposure to noxious stimuli. The method may be used both in vivo and in vitro. The method is effective in preventing calcium uptake in a variety of cell injury situations including metabolic inhibition and free radical attack.
REFERENCES:
patent: 4692433 (1987-09-01), Hostettler et al.
patent: 4719201 (1988-01-01), Foker
Claque, et al., "Cationic Amphiphiles Prevent Calcium Leak Induced by ATP Depletion in Myocardial Cells", Jan. 1993, pp. 214-218.
Burton; Superoxide dismutase enhances recovery following mycardial ischemic, Am. J. of Physiol.; 248:H637-H643 (1985).
Clague Jonathan R.
Langer Glenn A.
Post Jan A.
California Institute of Technology
Criares Theodore J.
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