Method for decontamination of mycoplasma-infected cell cultures

Details Method for decontamination of mycoplasma-infected cell cultures Method for decontamination of mycoplasma-infected cell cultures

1986-10-22

1990-01-23

Warren, Charles F.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352402, 4352403, 43524031, C12N 500, C12N 502

Patent

active

048958034

ABSTRACT:
A method for decontaminating cell cultures comprising contacting cell cultures with quinolone- and 1,8-naphthyridonecarboxylic acids of the formula (I) ##STR1## in which R.sup.1 represents methyl, ethyl, propyl, isopropyl, cyclopropyl, vinyl, 2-hydroxyethyl, 2-fluorethyl, methoxy, amino, methylamino, dimethylamino, ethylamino, phenyl, 4-fluorophenyl or 2,4-difluorophenyl,

REFERENCES:
patent: 4544658 (1985-10-01), Peterson et al.
patent: 4556658 (1985-12-01), Grohe et al.
McGarrity et al, "Methods of Prevention, Control and Elimination of Mycoplasma Infection"; in Mycoplasma Infection of Cell Cultures, McGarrity et al, editors, Plenum Press, N.Y., pp. 213, 235-241, 1978.
Journal Antimicrob. Chemother., Band 15, No. 6, Jun. 1985, pp. 787-789; fallon, R. J. et al, "In-Vitro Sensitiv. of Legionellas, menin., and Mycoplasmas to Cipro. and Enoxacin".
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Journal of Immunoglogical Methods, Band 109, No. 1, 1988, pp. 17-25, Elsevier Sci. Pub. B.V.; K. Schmitt et al: "A Safe and Efficient Method for Elimination of Cell Culture Mycoplasmas Using Ciproflox".
Perlman, "Use of Antibiotics in Cell Culture Media", Methods in Enzymology, vol. 58, 110-116, 1979.

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