Method for decomposing amyloid protein precursor and amyloid .be

Details Method for decomposing amyloid protein precursor and amyloid .be Method for decomposing amyloid protein precursor and amyloid .be

1996-04-30

1998-12-01

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 4, C12Q 137

Patent

active

058436952

ABSTRACT:
The present invention relates to a .beta.AP decomposing agent or a medicine for preventing and curing Alzheimer's disease, which contains, as the active ingredient, gelatinase A, a limited decomposate of gelatinase A, progelatinase A, a complex to which any of them has bonded or a material containing any of them. .beta.AP is a substance which is considered to cause Alzheimer's disease.

REFERENCES:
patent: 4902680 (1990-02-01), Aroonsakul
patent: 5221607 (1993-06-01), Cordell et al.
patent: 5252463 (1993-10-01), Nelson et al.
Ezzel, Science News, vol. 141, pp. 152-153, 1992.
Miyazaki et al, Biochemical and Biophysical Research Communications, vol. 185, No. 3, Jun. 30, 1992.
Miyazaki et al, Nature, vol. 362, pp. 839-841, Apr. 29, 1993.
Walsh, D.M., et al., "An Investigation into the Proteolytic Cleavage of Alzheimer Amyloid Precursor Protein in PC-12 Cells", Biochemical Society Transactions, vol. 22, No. 1, p. 14S, 1994.
K. Miyazaki et al. "Activation of TIMP-2/Progelatinase A Complex by Stromelysin," Biochemical and Biophysical Research Communications. vol. 185, No. 3, 1992. Jun. 30, 1992.
Hansjorg Kolkenbrock et al. "The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor," Eur. J. Biochem. 198, 775-781 (1991).
K. Miyazaki et al. "Gelatinase A and APP." Nature. vol. 368. 21 Apr. 1994.

Affiliated with

Also associated with

Rating

Method for decomposing amyloid protein precursor and amyloid .be does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for decomposing amyloid protein precursor and amyloid .be, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for decomposing amyloid protein precursor and amyloid .be will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2394823