Method for culturing T lineage precursor cells under conditions

Details Method for culturing T lineage precursor cells under conditions Method for culturing T lineage precursor cells under conditions

1995-09-11

1998-08-11

Knode, Marian C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435326, 435366, 4353727, 4353723, 435384, C12N 500, C12N 506, C12N 508

Patent

active

057926557

ABSTRACT:
The present invention provides culture methods of T lineage precursor cells comprising a step of culturing the T lineage precursor cells under a condition that a dissolved oxygen concentration in the nutrient medium is higher than a dissolved oxygen concentration in the nutrient medium when the medium is in contact with normal atmospheric air. According to the methods of the present invention, by using a submerged (suspension) culture which is a general method for culturing cells or tissues, the derivation of matured T cell(s) differentiated from T precursor cells in terms of their phenotypes of differentiation antigens and of their functions is realized to be accomplished.

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