Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1989-02-03
1992-08-18
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 88, 435 712, 435243, 435248, 435252, 4352521, 4352524, 4352536, 435832, A61K 3902, C12N 100
Patent
active
051397765
ABSTRACT:
There is disclosed a method for culturing Bordetella pertussis in the presence of a cellulose and/or cellulose derivatives. The present method is useful for obtaining a mixed antigen comprising pertussis toxin and filamentous hemagglutinin in a large amount at low cost. From the antigen, there can be obtained a stable and effective pertussis toxoid to be used for a pertussis vaccine. There is also disclosed a vaccine comprising the pertussis toxoid as an active ingredient and a gelatin and/or gelatin derivatives as a stabilizing agent. The present vaccine is extremely stable and can be stored for a prolonged period of time.
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Chazono Masashi
Konobe Takeo
Osame Juichiro
Takaku Keisuke
Yoshida Iwao
Brown Johnnie R.
Mohamed Abdel A.
The Research Foundation for Microbial Diseases of Osaka Universi
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