Method for crystallization of .alpha.-L-aspartyl-L-phenylalanine

Details Method for crystallization of .alpha.-L-aspartyl-L-phenylalanine Method for crystallization of .alpha.-L-aspartyl-L-phenylalanine

1994-02-28

1995-06-20

Straub, Gary P.

Chemistry: physical processes

Physical processes

Crystallization

530801, 560 40, 560 41, C07C22900

Patent

active

054257875

ABSTRACT:
The problems in crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester, namely, problems in crystal slurry properties in solid-liquid separation, scaling at heat transfer surfaces, and the like, are solved by a method for crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester which comprises cooling a solution of .alpha.-L-aspartyl-L-phenylalanine methyl ester by indirect heat exchange with a coolant while stirring, wherein the solution is cooled by circulating a coolant while continuously adding an aqueous solution of .alpha.-L-aspartyl-L-phenylalanine methyl ester dropwise to a crystallizing solution of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a temperature difference of not greater than 20.degree. C. from the coolant, thereby to keep a temperature difference of not greater than 20.degree. C. between the coolant and the crystallizing solution.

REFERENCES:
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patent: 5298648 (1994-03-01), Ebisawa et al.
patent: 5304671 (1994-04-01), Abe et al.
"Chemical Engineer's Handbook" by Perry et al; 5th ed.; McGraw-Hill N.Y.; 1973; pp. 10-38.

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