Method for crystallization of .alpha.-L-aspartyl-L-phenylalanine

Details Method for crystallization of .alpha.-L-aspartyl-L-phenylalanine Method for crystallization of .alpha.-L-aspartyl-L-phenylalanine

1994-10-21

1996-03-26

Straub, Gary P.

Chemistry: physical processes

Physical processes

Crystallization

530801, 560 40, 560 41, C07C22900, B01D 902

Patent

active

055017126

ABSTRACT:
The problems in crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester, namely, problems in crystal slurry properties in solid-liquid separation, scaling at heat transfer surfaces, and the like, are solved by a method for crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester which comprises cooling a solution of .alpha.-L-aspartyl-L-phenylalanine methyl ester by indirect heat exchange with a coolant while stirring, wherein the solution is cooled by circulating a coolant while continuously adding an aqueous solution of .alpha.-L-aspartyl-L-phenylalanine methyl ester dropwise to a crystallizing solution of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a temperature difference of not greater than 20.degree. C. from the coolant, thereby to keep a temperature difference of not greater than 20.degree. C. between the coolant and the crystallizing solution.

REFERENCES:
patent: 3901871 (1975-08-01), Anderson
patent: 4994605 (1991-02-01), Kishimoto et al.
patent: 5248806 (1993-09-01), Kishimoto et al.
patent: 5266719 (1993-11-01), Kishimoto et al.
patent: 5292923 (1994-03-01), Kato et al.
patent: 5298648 (1994-03-01), Ebisawa et al.
patent: 5304671 (1994-04-01), Abe et al.
"Chemical Engineers" Handbook by Perry et al., 5th ed., McGraw-Hill Book Co. (1973) pp. 10-38 to 10-39.

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