Method for coupling laser desorption to ion trap mass...

Radiant energy – Ionic separation or analysis – Cyclically varying ion selecting field means

Reexamination Certificate

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C250S293000, C250S288000, C250S282000, C250S291000, C250S292000, C250S297000

Reexamination Certificate

active

06878933

ABSTRACT:
The subject invention provides improved methods for injecting ions into a quadrupole ion trap mass spectrometer (QIT-MS). The methods of the subject invention are applicable to procedures involving atmospheric pressure laser desorption (AP-LD) of a sample to be investigated. Specifically, the subject invention involves controlling the pulse frequency of the laser such that the laser pulses are synchronized with changes in radiofrequency (RF) amplitude levels of the QIT-MS. Advantageously, by utilizing the methods of the subject invention it is possible to improve the accuracy and reproducibility of the results while improving duty cycle and reducing sample consumption.

REFERENCES:
patent: 5663562 (1997-09-01), Jones et al.
patent: 5965884 (1999-10-01), Laiko et al.
patent: 6534764 (2003-03-01), Verentchikov et al.
patent: 6545268 (2003-04-01), Verentchikov et al.
patent: 6670606 (2003-12-01), Verentchikov et al.
patent: 6683301 (2004-01-01), Whitehouse et al.
patent: 6762561 (2004-07-01), Kawato
patent: 20030141447 (2003-07-01), Verentchikov et al.
patent: 20040183007 (2004-09-01), Belov et al.
Coon, J.J. et al. “Atmospheric Pressure Laser Desorption/Chemical Ionization Mass Spectrometry: A New Ionization Method Based on Existing Themes”Rapid Communications in Mass Spectrometry,2002, pp. 681-685, vol. 16.
Coon, J.J. and Harrison, W.W. “Laser Desorption-Atmospheric Pressure Chemical Ionization Mass Spectrometry for the Analysis of Peptides from Aqueous Solutions”Anal. Chem.,Nov. 1, 2002. pp. 5600-5605, vol. 74 (indicates published on the Web Sep. 14, 2002).
Creaser, C.S. et al. “Structural Analysis of Oligosaccharides by Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionisation Quadrupole Ion Trap Mass Spectrometry”Rapid Communications in Mass Spectrometry,2002, pp. 176-184, vol. 16.
Galicia, M.C. “Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization in Transmission Geometry”Anal. Chem.,Apr. 15, 2002, pp. 1891-1895, vol. 74 (indicates published on the Web Mar. 16, 2002).
Keough, T. et al. “Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Ion Trap Mass Spectrometry of Sulfonic Acid Derivatized Tryptic Peptides”Rapid Communications in Mass Spectrometry2001, pp. 2227-2239, vol. 15.
Laiko, V.V. et al. “Atmospheric Pressure Laser Desorption/Ionization on Porous Silicon”Rapid Communications in Mass Spectrometry,2002, pp. 1737-1742, vol. 16.
Laiko, V.V. et al. “Atmospheric Pressure MALDI/Ion Trap Mass Spectrometry”Anal. Chem.,Nov. 1, 2000, pp. 5239-5243, vol. 72 (indicates published on the Web Sep. 23, 2000).
Laiko, V.V. et al. “Desorption/Ionization of Biomolecules from Aqueous Solutions at Atmospheric Pressure Using an Infrared Laser at 3 μm”Am. Soc. Mass. Spectrom,2002, pp. 354-361, vol. 13 (indicates published on-line Feb. 14, 2002).
Moyer, S.C. and Cotter, R.J. “Atmospheric Pressure MALDI”Anal. Chem.,Sep. 1, 2002, pp. 469-476.
Moyer, S.C. et al. “Fragmentation of Phosphopeptides by Atmospheric Pressure MALDI and ESI/Ion Trap Mass Spectrometry”J. Am. Soc. Mass. Spectrom.,2002, pp. 274-283, vol. 13 (indicates published on-line Jan. 22, 2002).

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