Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,... – Preparation composition
Patent
1992-07-21
1993-07-13
Rollins, John W.
Chemistry: analytical and immunological testing
Composition for standardization, calibration, simulation,...
Preparation composition
436 18, 436179, 252106, G01N 3100, C11D 348
Patent
active
052273040
ABSTRACT:
An improved multi-purpose blood diluent for use with a gentle lysing agent and improved detergent reagent system are disclosed which are especially suitable for use in routine electronic enumeration and volumetric differentation of blood cells. The preferred imidazole stabilizer used in the diluent reagent is found to be an excellent cell stabilizing agent and buffer for maintaining cell morphology during operation. A synergistic combination of a superior antimicrobial agent, the preferred Triadine-10, used in the diluent and the detergent reagents, not only prevents bacterial or fungal growth, but also helps to stabilize cells and to obtain distinct volumetric differentiation of certain leukocyte subpopulations. The preferred Brij 35 in a balanced salt solution has proved to be an efficient and cost effective detergent to ensure accurate results and trouble-free operation of the analyzers.
REFERENCES:
patent: 4962038 (1990-10-01), Carter et al.
patent: 5008202 (1991-04-01), Edmondson et al.
Rollins John W.
Schmidt Richard D.
Sequoia Turner Corporation
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