Method for counteracting vasospasms, ischemia, renal failure, an

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 21, 514929, A61K 3822, A61K 3823

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active

059588772

ABSTRACT:
The present invention provides a method for counteracting vasospasms and treating male impotence using calcitonin gene-related peptide (CGRP). CGRP is a naturally occurring substance in the human body. As such, CGRP does not have the same toxicity and allergy problems as the foreign substances that currently are used for similar purposes. When locally applied or infused, the effects of CGRP are limited to a local vascular area. Virtually no systemic effects are induced, making CGRP extremely safe and effective.

REFERENCES:
patent: 5214030 (1993-05-01), Stief
patent: 5290799 (1994-03-01), Misra et al.
patent: 5318531 (1994-06-01), Leone
patent: 5342348 (1994-08-01), Kaplan
patent: 5399352 (1995-03-01), Hanson
patent: 5550110 (1996-08-01), Cody et al.
patent: 5571523 (1996-11-01), Lee et al.
patent: 5576290 (1996-11-01), Hadley et al.
patent: 5637309 (1997-06-01), Tajima et al.
Jean McEwan, M.D., CH. B., "Calcitonin gene-related peptide: a potent dilator of human epicardial coronary arteries," Circulation, 74:6 (Dec. 1986) 1243-1247.
Peter F. Ludman, et al, "Effects of Calcitonin Gene-Related Peptide on Normal and Atheromatous Vessels and on resistance Vessels in the Coronary Circulation in Humans," Circulation, 84:5 (Nov. 1991) 1993-2000.
J.R. McEwan, M.B.CH.B., et al., "Vasodilation by calcitonin gene-related peptide and by substance P: a comparison of their effects on resistance and capacitance vessels of human forearms," Circulation, 77:5 (May 1988) 1072-1080.
Nobuyo Sekiguchi, MD, et al, "Effect of Calcitonin Gene-Related Peptide on Coronary Microvessels and Its Role in Acute Myocardial Ischemia," Circulation, 89:1, (Jan. 1994).
Sunil J. Wimalawansa, et al, "Isolation, Purification and Characterization of B-hCFRP From human Spinal Cord," Biochemical and Biophysical Research Communications, 167:3 (Mar. 1990) 993-1000.
Donald J. DiPette, et al. "Cardiovascular Actions of Calcitonin Gene-Related Peptide," Calcium Regulating Hormones and Cardiovascular Function, (Jun. 1995) 239-252.
Neal F. Uren, et al. "Effect of intravenous calcitonin gene related peptide of ischaemia threshold and coronary stenosis severity in humans," Cardiovascular Research, 27 (1993) 1477-1481.
David Ezra, et al., "Calcitonin gene-related peptide: a potent modulator of coronary flow," European Journal of Pharmacology, 137 (1987) 101-105.
Jacek, J. Preibisz, "Calcitonin Gene-Related Peptide and Regulation of Human Cardiovascular Homeostasis," American Journal of Hypertension, Ltd., 6:5 (May 1993) 435-450.
T. Shoji, et al. "Vasodilating effects of human and rat calcitonin gene-related peptides in isolated porcine coronary arteries," Naunyn-Schmiedeberg's Arch Pharmacol, 336 (Jul. 1987) 438-444.
Brian B. Quebbemen, et al, "Effect of Calcitonin Gene-Related Peptide on Well-Developed Canine Coronary Collateral Vasculature," Journal of Cardiovascular Pharmacology, 21:5 (1993) 774-780.
Sunil J. Wimalawansa, "Calcitonin: Molecular Biology, Physiology, Pathophysicology and its Theraputic Uses," 121-160, (not dated).
Michael G. Rosenfeld, et al. "Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing," Nature, 304 (Jul. 1983) 129-135.
Sunil J. Wimalawansa, "Use of Synthetic Peptides in Specific Affinity Chromatography for Purification of Specific Peptide Receptors" Inovation and Perspectives in Solid Phase Synthesis; (Peptides, Polypeptides and Oligonucleotides), (1992) 111-119.
Sunil J. Wimalawansa, "Isolation, Purification, and Biochemical Characterization of Calcitonin Gene-Related Peptide Receptors," Annals of the New York Academy of Science, 657 (1992) 70-87.
Howard R. Morris, et al. "Isolation and characterization of human calcitonin gene-related peptide," Nature, 308 (Apr. 1984) 746-748.
J.W.M. Hoppener, et al. "The second human calcitonin/CGRP gene is located on chromosome 11." Human Genetics, 70 (1985) 259-263.
P.H. Steenbergh, et al. "A second human calcitonin/CGRP gene," FEBS Letters, 183:2 (Apr. 1985) 403-407.

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