Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Patent
1995-05-23
1998-07-07
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
435180, 435181, 435182, C12N 1102, C12N 1108, C12N 1106, C12N 1104
Patent
active
057767475
ABSTRACT:
This invention relates to methods and compositions of controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments include (1) genetically manipulating cells, (2) exposing the cells to a proliferation-inhibiting compound or a differentiation-inducing compound or removing the cells from exposure to a proliferation-stimulating compound or a differentiation-inhibiting compound; exposing the cells to irradiation, and (3) modifying a growth surface of the BAO with ECM molecules, molecules affecting cell proliferation or adhesion, or an inert scaffold, or a combination thereof. These treatments may be used in combination. A particular embodiment is directed to derivatizing or adsorbing polyethylene oxide-poly(dimethylsiloxane) copolymer (PEO-PDMS) onto a surface within the bioartificial organ to inhibit cellular attachment.
REFERENCES:
patent: 4391909 (1983-07-01), Lim
patent: 4402694 (1983-09-01), Ash et al.
patent: 4489796 (1984-12-01), Kallok
patent: 4495288 (1985-01-01), Jarvis Jr. et al.
patent: 4829000 (1989-05-01), Kleinman et al.
patent: 5002661 (1991-03-01), Chick et al.
patent: 5049493 (1991-09-01), Khosla et al.
patent: 5082670 (1992-01-01), Gage et al.
patent: 5106627 (1992-04-01), Aebischer et al.
patent: 5156844 (1992-10-01), Aebischer et al.
patent: 5158881 (1992-10-01), Aebischer et al.
patent: 5250414 (1993-10-01), Schwab et al.
patent: 5283187 (1994-02-01), Aebischer et al.
patent: 5284761 (1994-02-01), Aebischer et al.
Kleinman, Hynda K., and Benjamin S. Weeks, "The Neural Cell Response to Laminin: Active Sites, Receptors, and Intracellular Signals," Comments Developmental Neurobiology, pp. 251-266 (1991).
Farghali et al., The concept of Application of Immobilized and Perfused Mammalian cells (a bioreactor model) in biomedical research, Physiological Research, 43, pp. 117-120 (1994).
Adhya, Sankar, et al., "Promoter resurrection by activators--a minireview," Gene , 132, pp. 1-6 (1993).
Arnheiter, Heinz, et al., "Transgenic Mice with Intracellular Immunity to Influenza Virus," Cell , 62, pp. 51-61 (1990).
Aulthouse, Amy Lynn, et al., "Expression of the Human Chondrocyte Phenotype in Vitro," In Vitro Cellular & Developmental Biology , 25, pp. 659-668 (1989).
Baetge, E. Edward, et al., "Complete Nucleotide and Deduced Amino Acid Sequence of Bovine Phenylethanolamine N-methyltransferase: Partial Amino Acid Homology with Rat Tyrosine Hydroxylase," Proc. Natl. Acad. Sci. USA, 83, pp. 5454-5458 (1986).
Barinaga, Marcia, "Knockout Mice: Round Two," Science , 265, pp. 26-28 (1994).
Baron-Van Evercooren, A., et al., "Schawann Cell Differentiation in vitro: Extracellular Matrix Deposition and Interaction," Dev. Neurosci., 8, pp. 182-196 (1986).
Blau, Helen M., et al., "Myoblasts in Pattern Formation and Gene Therapy," Trends in Genetics, 9, pp. 269-274 (1993).
Bohak, Z. et al., "Novel Anchorage Matrices for Suspension Culture of Mammalian Cells," Biopolymers, 26, pp. S205-S213 (1987).
Brenner, Michael, et al., "GFAP Promoter Directs Astrocyte-specific Expression in Transgenic Mice," The Journal of Neuroscience, 14, pp. 1030-1037 (1994).
Brinster et al., "Factors Affecting the Efficiency of Introducing Foreign DNA into Mice by Microinjecting Eggs," Proc. Natl. Acad. Sci. USA, 82, pp. 4438-4442 (1985).
Cabasso, Israel, "Hollow-Fiber Membranes," Encyclopedia of Chemical Technology (Kirk-Othmer, ed.), pp. 492-517 (1980).
Carbonetto, Salvatore "Ch. 15: Laminin Receptors: From PC12 Cells to PNS," Brain Repair (Bjorklund, Aguayo and Ottson, eds.), pp. 185-197 (1990).
Celtrix Laboratories, "Vitrogen 100.RTM.: Purified Collagen for Cell Culture and Biochemistry" (Product Information Memorandum), Celtrix Laboratories, Palo Alto, CA (1991).
Cepko, Connie, "Retrovirus Vectors and Their Applications in Neurobiology," Neuron, 1, 345-353 (1988).
Chang, P.L., et al., "Delivery of Recombinant Gene Products with Microencapsulated Cells In Vivo,"Human Gene Therapy, 4, pp. 433-440 (1993).
Chu, C.H., and A.M. Tolkovsky, "Alternative Adrenal Chromaffin Cell Fates Induced by Basic Fibroblast Growth Factor or Cyclic AMP In Vitro Depend on a Collaboration With The Growth Substrate," Neuroscience, 59, pp. 43-54 (1994).
Collaborative Research Incorporated, "CR-Laminin and CR-Anti-Laminin" (Product Information Memorandum), Collaborative Research, Inc., Bedford, MA (1987).
Collaborative Research Incorporated, "Basement Membrane Matrigel.TM." (Product Specification Sheet), Collaborative Research, Inc., Bedford, MA (1991).
Collagen Biomedical, "Collagen Test Implant Physician Package Insert," (Product Information Literature), Collagen Biomedical, Palo Alto, CA (1992).
Collagen Biomedical "Zyderm.RTM.Collagen and Zyderm.RTM.Explained," (Product Information Memorandum), Collagen Biomedical, Palo Alto, CA (1992).
Collagen Biomedical, "Zyderm.RTM.Collagen Implant Physician Package Insert," (Product Literature), Collagen Biomedical, Palo Alto, CA (1992).
Collagen Biomedical, "Zyplast.RTM.Implant Physician Package Insert," (Product Literature), Collagen Biomedical, Palo Alto, CA (1992).
Crouch, Gary D., et al., "Ara-C Treatment Leads to Differentiation and Reverses the Transformed Phenotype in a Human Rhabdomyosarcoma Cell Line," Experimental Cell Research, 204, pp. 210-216 (1993).
Datta, Dipak B., "Keeping In Touch: The Adhesion Reactions of the Cell Membrane," A Comprehensive Introduction to Membrane Biochemistry, pp. 231-56 (1987).
de Bruine, Adriaan P., et al., "Extracellular Matrix Components Induce Endocrine Differentiation in Vitro in NCI-H716 Cells," American Journal of Pathology, 142, pp. 773-782 (1993).
De Loecker, William, et al., "Effects of Sodium Ascorbate (Vitamin C) and 2-Methyl-1,4-naphthoquinone (Vitamin K.sub.3) Treatment of Human Tumor Cell Growth in Vitro. II. Synergism with Combined Chemotherapy Action," Anticancer Research, 13, pp. 103-106 (1993).
Edgar, David, "Neuronal laminin receptors," TINS, pp. 248-251 (1989).
El-Deiry, Wafik S., et al., "WAF1, a Potential Mediator of p53 Tumor Suppression,"Cell, 75, pp. 817-825 (1993).
End, Peter, and Jurgen Engel, "Multidomain Proteins of the Extracellular Matrix and Cellular Growth," Receptors for Extracellular Matrix (McDonald, J. and Mecham, R., ed.), pp. 79-129 (1991).
Epstein-Baak, Ruth, et al., "Inducible Transformation of Cells from Transgenic Mice Expressing SV40 under lac Operon Control," Cell Growth and Differentiation, 3, pp. 127-134 (1992).
Fattaey, H.K., et al., "Modulation of Growth-Related Gene Expression and Cell Cycle Synchronization by a Sialoglycopeptide Inhibitor," Experimental Cell Research, 194, pp. 62-68 (1991).
Fattaey, Heideh, et al., "Inhibition of DNA Synthesis and Cell Division by a Cell Surface Sialoglycopeptide," Journal of Cellular Physiology, 139, pp. 269-274 (1989).
Fujiyama, C., et al., "Influence of Extracellular Matrix on the Proliferation and Differentiation of Adrenocortical Cells in Culture," Path. Res. Pract., 189, pp. 1205-1214 (1993).
Galli, Maria C., et al., "The Biology of Stem Cell Factor, a New Hematopoietic Growth Factor Involved in Stem Cell Regulation," Int. J. of Clin. Lab. Res., 23, pp. 70-77 (1993).
Gash, D.M., et al., "Amitotic Neuroblastoma Cells Used for Neural Implants in Monkeys," Science, 233, pp. 1420-1422 (1986).
Gonos, Efstathios S., and Demetrios A. Spandidos, "Oncogenes in Cellular Immortalisation and Differentiation (Review)," Anticancer Research, 13, pp. 1117-1122 (1993).
Grabham, Peter W., et al., "Vibronectin Is the Major Serum Protein Essential for NGF-Mediated Neurite Outgrowth from PC12 Cells," Experimental Cell Research, 202, pp. 337-44 (1992).
Graf, Jeannette, et al., "A Pentapeptide form the Laminin .beta.1 Chain Mediates Cell Adhesion and Binds the 67 000 Laminin Receptor," Biochemistry , 26, pp. 6896-6900 (1987).
Graf, Jeannette, et al., "Identification of an Amino Acid Sequence in Laminin Mediating Cell Attachment, Chemotaxis, and Receptor Binding," Cell , 48, pp. 989-996 (1987)
Aebischer Patrick
Cain Brian M.
Doherty Edward J.
Gentile Frank T.
Hammang Joseph P.
Cytotherapeutics, Inc.
Elrifi Ivor R.
Saucier Sandra E.
LandOfFree
Method for controlling the distribution of cells within a bioart does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for controlling the distribution of cells within a bioart, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for controlling the distribution of cells within a bioart will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1204515