Method for controlling the amount and distribution of alkaloids

Details Method for controlling the amount and distribution of alkaloids Method for controlling the amount and distribution of alkaloids

1981-02-06

1983-06-28

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435911, C12P 1718, C12R 1645

Patent

active

043906257

ABSTRACT:
The invention relates to a new method for controlling the level and distribution of alkaloids produced by Claviceps purpurea variant strains capable of producing primarily ergocornine, .alpha.-ergocryptine and .beta.-ergocryptine under saprophytic conditions. According to the invention a compound of the biosynthesis path of isoleucine or a compound which promotes the formation of isoleucine by biochemical control is added to the fermentation broth. In other respects fermentation is performed under conditions known per se.
By the method of the invention the ratio of .alpha.- and .beta.-ergocryptine formed in the fermentation broth can be adjusted to the optimum value.

REFERENCES:
patent: 2835675 (1958-05-01), Abe et al.
patent: 3110651 (1963-11-01), Kybal et al.
patent: 3884762 (1975-05-01), Wock et al.
Czechoslovakian Inventor's Certificate CS202613 with accompanying English translation.

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