Coating processes – Particles – flakes – or granules coated or encapsulated
Reexamination Certificate
2007-08-14
2007-08-14
Tsoy, Elena (Department: 1762)
Coating processes
Particles, flakes, or granules coated or encapsulated
C427S222000, C106S031130, C106S031270
Reexamination Certificate
active
10348165
ABSTRACT:
Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.
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PCT International Search Report (enclosed).
Banerjee Sukanta
Georgescu Cecilia
Seul Michael
BioArray Solutions Ltd.
Mirabel Eric
Monaco Dan
Tsoy Elena
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