Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated to proteinaceous toxin or fragment thereof
Patent
1991-12-10
1997-09-23
Scheiner, Toni R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated to proteinaceous toxin or fragment thereof
4241431, 4241781, 53038822, A61K 39395, A61K 3940, A61K 3942, A61K 3944
Patent
active
056701519
ABSTRACT:
A method for controlling the overgrowth of hyperproliferating cells in the presence of non-proliferating cells by exposing the hyperproliferating cells to a toxin conjugate that has a binding region that binds to an internalizable element of the hyperproliferating cell and a toxic moiety bound thereto is provided. The toxin conjugate may be a monoclonal antibody to transferrin receptor. Such toxin conjugates will have use in controlling hyperproliferative diseases of the integument and the eye.
REFERENCES:
patent: 4434156 (1984-02-01), Trowbridge
patent: 4830962 (1989-05-01), Gelfand et al.
patent: 4894443 (1990-01-01), Greenfield et al.
Fulcher, S. et al. (II), "Use of Immunotoxin to Inhibit Proliferating Human Corneal Endothelium," Invest. Ophthalmol. Visual. Sci. 29(5): 755-759, May 1988.
Trowbridge, I.S. et al. "Anti-transferrin receptor monoclonal antibody and toxin--antibody conjugates affect growth of human tumor cells," Nature 294: 171-173, Nov. 12 ,1981.
Ramakrishan, S., 1984, Science, 223:58-61.
Van Bockxmeer, F.M. et al., 1982, J. Tissue Culture Methods, 7:163-167.
Fastenberg, D.M, et al., 1982, Am. J. Ophthalmol., 93: 565-572.
Fastenberg, D.M., et al., 1982, Am. J. Ophthalmol., 93:559-564.
Fulcher, S., et al., (I), "Effect of an Immunotoxin Containing Ricin A Chain and Monoclonal Antibody Against the Transferrin Receptor on the Proliferation of Human Corneal Endothelium", Annual Spring Meeting of the Association for Research in Vision and Ophthamology Incorporated, Sarasota, Fla, USA, Apr. 28-May 2, 1986, Invest Ophthalmology Visual Science,27 (3 Suppl.):69, 1986.
Groves Eric S.
Houston L. L.
Larrick James W.
Blackburn Robert P.
Chiron Corporation
Green Grant D.
Huff Sheela J.
McCracken Thomas P.
LandOfFree
Method for controlling hyperproliferative diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for controlling hyperproliferative diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for controlling hyperproliferative diseases will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1937835