Method for controlling hemophilia in mammals

Details Method for controlling hemophilia in mammals Method for controlling hemophilia in mammals

1983-06-27

1985-08-20

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424199, 514786, A61K 3516

Patent

active

045363927

ABSTRACT:
A method for controlling HemophiliaA (Antihemophilic Factor (F. VIII:C) deficiency) in mammals is described. Factor VIII:C deficiency in the mammal is bypassed by infusion of a synergistic mixture of a phospholipid and Factor Xa so that the cascade process of blood clotting may continue. The proportions of phospholipid and Factor Xa in the mixture are critical as too little Xa has no effect while too much is toxic (thrombogenic).

REFERENCES:
Nesheim et al.-J. of Biol. Chem., vol. 256, No. 13, Jul. 1981, pp. 6537-6540.
Giles et al.-Blood-vol. 59, No. 2, (Feb. 1982), pp. 401-407.
Nesheim et al.-Chem. Abst., vol. 95, (1981), p. 112612u.

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