Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-05-19
1991-07-16
Doll, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, 530858, 530855, 514 2, A61K 3702
Patent
active
050325760
ABSTRACT:
A pheromone biosynthesis activating neuropeptide (Hez-PBAN) hormone, controlling sex pheromone production in moths and controlling melanizing in larvae, was isolated from the brain-suboesophageal ganglion complexes of adult corn earworm Heliothis zea. Hez-PBAN has 33 amino acide residues and a molecular weight of 3900; its amino acid sequence is unique among the fully characterized peptide hormones. Synthetic PBAN and related structures induced production of sex pheromone in ligated H. zea females and other moth species and melanization in larvae that resulted in morphological changes or death.
REFERENCES:
Biochem. and Biophys. Res. Com., vol. 135, No. 2, (1986) pp. 622-628, Jaffa et al.
Chem. Abs. 108 (21), 182947t, (1988), Matsumoto et al.
Chem. Abs. 105(17), 150065a, (1986) Matsumoto et al.
A. K. Raina & J. A. Klun, "Brain Factor Control of Sex Pheromone Production in the Female Corn Earworm Moth," Science 225: 531-533 (1984).
H. Jaffe et al., "HPLC Isolation and Purification of Pheromone Biosynthesis Activating Neuropeptide of Heliothis zea," In Insect Neurochemistry and Neurophysiology, A.B. Borkovec and D. B. Genman, eds., pp. 219-224, Humana Press, Clifton, N.J. (1986).
A. K. Raina et al., "Characteristics of a Neurohorone That Controls Sex Pheromone Production in Heliothis zea," J. Insect Physiol. 33: 809-814 (1987).
H. Nagasawa et al., "Isolation of Pheromone Biosynthesis Activating Neuropeptide of the Silkworm, Bombyx mori," Agric. Biol. Chem. 52: 2985-2987 (1988).
Jaffe Howard
Kempe Thomas G.
Raina Ashok K.
Doll John
Sadowski David R.
Silverstein M. Howard
The United States of America as represented by the Secretary of
Wessendorf T. D.
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