Method for controlling emesis with N-(1-substituted-3-pyrrolidin

Details Method for controlling emesis with N-(1-substituted-3-pyrrolidin Method for controlling emesis with N-(1-substituted-3-pyrrolidin

1974-10-25

1976-06-15

Moyer, Donald B.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032683, 424274, C07D20714, A61K 3140

Patent

active

039637450

ABSTRACT:
A method is disclosed for controlling emesis utilizing N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides of the formula: ##SPC1##
Wherein R is cycloalkyl, phenyl and phenyllower-alkyl; R.sup.1 is hydrogen, lower alkyl of 1 to 8 carbon atoms and phenyl; R.sup.2 is halogen, lower-alkyl, lower-alkoxy, amino, nitro, monoalkylamino, dialkylamino, mercaptomethyl, acetamido, sulfamoyl, cyano, hydroxy, benzyloxy, and trifluoromethyl; X is oxygen and sulfur; n is an integer from zero to three inclusive and pharmaceutically acceptable acid addition salts thereof. The benzamide compounds wherein R is cyclohexyl and R.sup.1 is lower-alkyl are particularly effective as antiemetics and have minimal side effects.

REFERENCES:
patent: 3342826 (1967-09-01), Miller et al.
patent: 3577440 (1971-05-01), Lunsford et al.
patent: 3812170 (1974-05-01), Bretschneider et al.
patent: 3862139 (1975-01-01), Podesva et al.

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