Method for controlling bleeding

Details Method for controlling bleeding Method for controlling bleeding

1985-08-09

1988-01-26

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

514 2, 514 76, 514781, 514786, A61K 3516

Patent

active

047216182

ABSTRACT:
Factor VIII:C deficiency in a hemophilic mammal may be bypassed by infusion of a synergistic mixture of a phospholipid and Factor Xa so that the cascade process of blood clotting may continue. The proportions of phospholipid and Factor Xa in the mixture are critical as too little Xa has no effect while too much is toxic (thrombogenic). Infusion of the phosphilipid-Factor Xa mixture into normal mammals enhances the natural clotting rate and provides a method for rapidly controlling bleeding in emergency situations.

REFERENCES:
Nesheim et al., J. Biol. Chem., vol. 256, No. 13, Jul. 1981, pp. 6537-6540.
Giles et al., Blood, vol. 59, No. 2 (Feb. 1982), pp. 401-407.
Kosow et al., J. Biol. Chem., vol. 254, No. 19, (1979), pp. 9448-9452.

Affiliated with

Also associated with

Rating

Method for controlling bleeding does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for controlling bleeding, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for controlling bleeding will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1467479