Method for controlling axial length of the eye

Details Method for controlling axial length of the eye Method for controlling axial length of the eye

1997-03-13

2000-01-04

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9464, 514 2, 514 12, A61K 3849, A61K 3816

Patent

active

060106999

ABSTRACT:
A method for controlling axial length, comprising administering a pharmaceutically effective amount of a TGF-.beta. regulating substance. More particularly, a method for inhibiting axial elongation and a method for the prophylaxis and treatment of myopia, both comprising administering a TGF-.beta. activator, specifically a plasminogen activator. A method for elongation of axial length and a method for the prophylaxis and treatment of hyperopia, both comprising administering a TGF-.beta. activation inhibitor, particularly a plasminogen activator inhibitor. The method for controlling axial length of the present invention is extremely useful for the prophylaxis and treatment of myopia or hyperopia. It is also useful for preparing experimental model animals having eyes with complete axial myopia or hyperopia exclusive of refractive myopia or hyperopia.

REFERENCES:
patent: 5652209 (1997-07-01), Pflugfelder et al.
patent: 5656726 (1997-08-01), Rosenberg et al.
patent: 5688765 (1997-11-01), Sullivan
O'Brart et al., Ophthalmology, 101(9):1565-74, 1994.
Honda et al., Invest. Ophthalmol. Vis. Sci., 37(12):2519-26, Nov. 1996.
Rohrer et al., Experimental Eye Research, 58(5):553-561.

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